alexa Rapid and systematic identification of indole alkaloids
e-ISSN: 2321-6182 p-ISSN: 2347-2332

Research & Reviews: Journal of Pharmacognosy and Phytochemistry
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Research Article

Rapid and systematic identification of indole alkaloids in Uncaria rhynchophylla by UPLC-Q-TOF-MS

Ying Liu1,3, Guixiang Pan1*, Xiaoming Wang1, Ndagijimana Andre1,2, Peng Wang1,3, Yuan Yuan1,3, Tingting Li1,3

1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, PR China

2 Institute of Scientific and Technological Research (IRST), Rwanda

3Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, 300457, PR China

 

*Corresponding Author:
Guixiang Pan
Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,88 Yuquan Road, Tianjin 300193, PR China
E-mail: [email protected]

Received: 22 April 2015 Accepted: 29 May 2015 Published: 27 June 2015

 

Abstract

Uncaria rhynchophylla (UR), a well-knowntraditional Chinese medicine (TCM), is widely used to treat clinical cardiovascular diseases. Recently, some researches have been reported for pharmacology and photochemistry of UR. However, there are no reports on qualitative analysis previously. We used MDF function module of Agilent qualitative software and characteristic diagnostic fragmentation ions (CDFI) to identify Uncaria alkaloids. A total of thirty-two compounds were identified. Among them, twelve ingredients had never been reported in a qualitative way, including three ajmalicine-type (16,20,21), four yohimbine-type (4,5,15,27), 5α-carboxystrictosidine (6), gambireine (10), glabratine (12), villocarines D (17) and geissoschizine methyl ether (23).A rapid method integrated MDF and diagnostic ions is successfully established and applied to identify the alkaloids in UR.

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