alexa Rapid Microwave-Assisted Synthesis of Modified Pyrimidi
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Mini Review

Rapid Microwave-Assisted Synthesis of Modified Pyrimidine and Purine Pyranonucleosides as Novel Cytotoxic, Antiviral Agents and Glycogen Phosphorylase B Inhibitors

Manta S1, Dimopoulou A2, Kollatos N2, Kyrkou G2, Spanos S2 and Komiotis D2*

1Department of Chemistry, University of Cyprus, Nicosia, Cyprus

2Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece

*Corresponding Author:
Komiotis D
Laboratory of Bioorganic Chemistry
Department of Biochemistry and Biotechnology
University of Thessaly, Viopolis, 41500 Larissa, Greece
Tel: 302410565290
E-mail:
[email protected]

Received date: April 27, 2017; Accepted date: May 05, 2017; Published date: May 10, 2017

Citation: Manta S, Dimopoulou A, Kollatos N, Kyrkou G, Spanos S, et al. (2017) Rapid Microwave-Assisted Synthesis of Modified Pyrimidine and Purine Pyranonucleosides as Novel Cytotoxic, Antiviral Agents and Glycogen Phosphorylase B Inhibitors. Med Chem (Los Angeles) 7:129-132. doi: 10.4172/2161-0444.1000443

Copyright: © 2017 Manta S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Nucleosides take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. The chemistry of substituted base-modified nucleosides has been an interesting field of study over the last two decades owing to their biological properties. This mini-review summarizes recent efforts on the synthesis of C5- and C8-alkynyl base-modified pyranonucleoside analogues using Sonogashira cross-coupling reaction under microwave irradiation.

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