alexa Rare Extramedullary Relapse of Acute Myeloid Leukemia Manifested as Granulocytic Sarcoma of the Breast: Imaging Findings and Pathology Correlation
ISSN: 2168-9784

Journal of Medical Diagnostic Methods
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Case Report

Rare Extramedullary Relapse of Acute Myeloid Leukemia Manifested as Granulocytic Sarcoma of the Breast: Imaging Findings and Pathology Correlation

Limin Yang1*, Jeong Mi Park1, Ryan W. Askeland2 and Laurie L. Fajardo1
1Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
2Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
Corresponding Author : Limin Yang, MD, PhD
Department of Radiology
University of Iowa Hospitals and Clinics
Iowa City, Iowa
Tel: 319-353-6339
Fax: 319-356-2220
E-mail: [email protected]
Received April 25, 2012; Accepted May 16, 2012; Published May 21, 2012
Citation: Yang L, Park JM, Askeland RW , Fajardo LL (2012) Rare Extramedullary Relapse of Acute Myeloid Leukemia Manifested as Granulocytic Sarcoma of the Breast: Imaging Findings and Pathology Correlation. J Med Diagn Meth 1:103. doi:10.4172/2168-9784.1000103
Copyright: © 2012 Yang L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

We present two cases of granulocytic sarcoma of the breast in women who had a prior history of Acute Myeloid Leukemia (AML). Both patients presented with a palpable breast mass (one patient with a right breast mass and the other patient with bilateral breast masses) within one year following allogeneic peripheral blood stem cell transplantation for AML. Ultrasound-guided biopsy of the breast masses showed granulocytic sarcoma, a rare tumor without obvious primary bone marrow involvement. Reports of bilateral breast involvement with granulocytic sarcoma following allogeneic peripheral blood stem cell transplantation for AML are rare. Granulocytic sarcoma should be considered in the differential diagnosis of a new palpable breast mass in patients with a history of malignant hematologic tumor treated by allogeneic peripheral blood stem cell transplantation.

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