alexa Ras Signaling Pathway, Historical View | OMICS International | Abstract
ISSN: 2157-7013

Journal of Cell Science & Therapy
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Ras Signaling Pathway, Historical View

Fahad G B Alanazi1, Badi Q Alenazi1, Abdulaziz D Al-Faim1, Omar Bagadir1, Ali Al-Shangiti1, Omar Kujan2, Bassel Tarakji2, Saeed M Daboor2, Mohamed W Al-Rabea3, Waleed Tamimi4, Dhaifallah Alenizi5, Entissar AlSuhaibani6 and Faris Q Alenzi7*

1MOH, Riyadh, Saudi Arabia

2Al-Farabi Dental College, Riyadh, Saudi Arabia

3College of Medicine, King Abdulaziz Univ., Jeddah, KSA

4Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, Riyadh, Saudi Arabia

5College of Medicine, North Borders Univ., Arar, Saudi Arabia

6College of Science, KSU, Riyadh, Saudi Arabia

7College of Appl Med Sci. Salman bin Abdulaziz University, Al-Kharj, Saudi Arabia

*Corresponding Author:
Faris Q Alenzi
College of Applied Medical Sciences
P.O.Box 422 Al-Kharj 11942, Saudi Arabia
Tel: 4693558
E-mail: [email protected]

Received Date: July 07, 2014; Accepted Date: July 18, 2014; Published Date: July 31, 2014

Citation: Alanazi FGB, Alenazi BQ, Faim ADA, Bagadir O, Shangiti AA, et al. (2014) Ras Signaling Pathway, Historical View. J Cell Sci Ther 5:e117. doi: 10.4172/2157-7013.1000e117

Copyright: © 2014 Alanazi FGB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


It is increasingly clear that the three RAS genes, N-. H- and K-RAS, encode 21 kDa proteins which act as intracellular switches, play a signal transduction pathway in controlling cell growth and differentiation. The three genes are highly homologous, yet recent evidence suggests they may have distinct functions in different cell types and have a central role in many human diseases. This article reviews briefly the regulation of signaling mechanisms.

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