alexa Recalcitrant Hyperkalaemia Associated with a Single Dose Administration of Zoledronic Acid for Treatment of Post-Menopausal Osteoporosis | OMICS International
ISSN: 2329-9509

Journal of Osteoporosis and Physical Activity
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Case Report

Recalcitrant Hyperkalaemia Associated with a Single Dose Administration of Zoledronic Acid for Treatment of Post-Menopausal Osteoporosis

Jerry Yongqiang Chen1*, Leon Siang Shen Foo2
1Department of Orthopaedic Surgery, Singapore General Hospital, Singapore
2Island Orthopaedic Consultants Mount Elizabeth Medical Centre, Singapore
Corresponding Author : Jerry Yongqiang Chen
Department of Orthopaedic Surgery
Singapore General Hospital
Academia Building Level 4
Outram Road, Singapore 119228
Tel: +65-93681926
Fax: +65-62248100
E-mail: [email protected]
Received October 05, 2013; Accepted November 02, 2013; Published November 09, 2013
Citation: Chen JY (2013) Recalcitrant Hyperkalaemia Associated with a Single Dose Administration of Zoledronic Acid for Treatment of Post-Menopausal Osteoporosis . J Osteopor Phys Act 1:105. doi: 10.4172/2329-9509.1000105
Copyright: © 2013 Chen JY. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Hyperkalaemia is a very rare complication associated with zoledronic acid. We report the case of a patient with hyperkalaemia recalcitrant to treatment. A 72 year-old woman who was diagnosed with post-menopausal severe osteoporosis following a bone mineral density scan was treated with a single dose of zoledronic acid infusion. After 3 weeks, the patient’s serum potassium level increased from a baseline of 3.8 mmol/L to 5.9 mmol/L. Renal function was normal and all other possible causes of hyperkalaemia were excluded. She was started on oral sodium polystyrene sulfonate 15 g twice daily. Her serum potassium level remained persistently elevated over the next 9 weeks before it finally returned to a normal level on the 13th week after zoledronic acid infusion. We recommend close monitoring and prompt treatment of hyperkalaemia should it occur.

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