Recent Advances in Molecular Targeted Therapy for advanced Colorectal Cancer and Non–Small Cell Lung Cancer
Received Date: Jul 10, 2012 / Accepted Date: Oct 27, 2012 / Published Date: Oct 29, 2012
Cancer remains one of the most life-threatening diseases to date. Traditionally, chemotherapy treatments for locally advanced or metastatic cancer had little or no efficacy. For example, colon and lung cancers were associated with poor clinical outcomes as recently as a decade ago. However, increased understanding of the molecular mechanisms underlying carcinogenesis has spurred focus on the development and incorporation of molecular targeted agents in current therapeutic options for these difficult-to-treat diseases. Such agents have the ability to target a variety of cancer relevant molecules, including epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) and its receptor. In addition, protein tyrosine kinases have been proven to be good targets to develop small molecule inhibitors that compete with ATP and inhibit kinase activity. These inhibitors have clinically effective responses. In this review, we describe the current status of targeted therapies in the treatment of advanced colon and lung cancers
focusing on clinical data based on experience with in monoclonal antibodies and tyrosine kinase inhibitors acting in these pathways.
Keywords: Molecular-targeted drug; Chemotherapy; CRC; NSCLC; Review
Citation: Tanaka T, Tamura K (2012) Recent Advances in Molecular Targeted Therapy for advanced Colorectal Cancer and Non–Small Cell Lung Cancer. J Phys Chem Biophys 2:108 Doi: 10.4172/2161-0398.1000108
Copyright: © 2012 Tanaka T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
- Total views: 12858
- [From(publication date): 12-2012 - Dec 19, 2018]
- Breakdown by view type
- HTML page views: 9057
- PDF downloads: 3801