Recent Development of Benzotriazole-based Medicinal DrugsYu Ren, Ling Zhang, Cheng-He Zhou and Rong-Xia Geng*
Institute of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People’s Republic of China
- *Corresponding Author:
- Rong-Xia Geng
School of Chemistry and Chemical Engineering
Southwest University, Chongqing 400715
People’s Republic of China
E-mail: mailto:[email protected]
Received date: June 24, 2014; Accepted date: August 18, 2014; Published date: August 20, 2014
Citation: Ren Y, Zhang L, Zhou CH, Geng RX (2014) Recent Development of Benzotriazole-based Medicinal Drugs. Med chem 4:640-662. doi:10.4172/2161-0444.1000207
Copyright: © 2014 Ren Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The extensively clinical use of triazole-based medicinal drugs has been promoting increasing effort to develop new structural triazole derivatives. Benzotriazoles as fused aromatic nitrogen heterocycles of benzene ring with triazole exhibit wide potentialities in medicinal chemistry since some anticancer benzotriazole compounds like vorozole and 4,5,6,7-tetrabromo-1H-benzotriazole (TBB) were used in clinical therapy. The benzotriazole related investigations are becoming increasingly active. On the basis of authors’ researches and other literature in recent five years, this work for the first time gave a comprehensive review on the latest and outstanding developments of benzotriazole compounds in medicinal chemistry, including as anticancer, antifungal, antibacterial, antitubercular, antiviral, antioxidative, antiparasitic, antioxidative agents and so on. Hopefully, this contribution will be helpful to develop benzotriazole-based drugs with high bioactivity and low toxicity.