Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring
GRD (PG) Institute of Management and Technolgy, Dehradun, 248009 (UK), India
- *Corresponding Author:
- Mohammad Asif
GRD (PG) Institute of Management and Technolgy
Dehradun, 248009 (UK), India
E-mail: [email protected]
Received date: December 11, 2012; Accepted date: December 27, 2012; Published date: December 29, 2012
Citation: Asif M (2012) Recent Efforts for the Development of Antitubercular Drug Containing Diazine Ring. Med chem 2:151-167. doi:10.4172/2161-0444.1000133
Copyright: © 2012 Asif M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
There has been considerable interest in the development of new molecule with antibacterial activities particularly against tuberclosis because mycobacterium species have developed resistant against currently used drugs, their toxic effect and long duration of therapy. The diazine (pyridazine, pyrimidine and piperazine) derivatives possess an important class of compound for new drugs research and development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their antitubercular activity. These observations have been guiding for the development of new molecules that possess potent antitubercular activity with minimum side effects or effective against MDR, XDR mycobacterium strains, and also in patient co-infected with HIV/AIDS.