alexa Red Blood Cell Transfusion in Sepsis: A Review
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

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Special Issue Article

Red Blood Cell Transfusion in Sepsis: A Review

Farid Sadaka*

Mercy Hospital St Louis/St. Louis University Hospital, Critical Care Medicine, New Ballas Rd, suite 4006B, St Louis, MO 63141, USA

Corresponding Author:
Farid Sadaka
Mercy Hospital St Louis/St. Louis University Hospital
Critical Care Medicine, New Ballas Rd
suite 4006B, St Louis, MO 63141, USA
Tel: 314-251 6486
Fax: 314-251-4155
E-mail: [email protected]

Received Date: May 07, 2012; Accepted Date: May 30, 2012; Published Date: June 05, 2012

Citation: Sadaka F (2012) Red Blood Cell Transfusion in Sepsis: A Review. J Blood Disord Transfus S4:001. doi:10.4172/2155-9864.S4-001

Copyright: © 2012 Sadaka F. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Sepsis is very common and lethal. Sepsis is the leading cause of death in non-coronary Intensive Care Units, and the tenth leading cause of death overall. Red blood cell transfusion is one of the most commonly used interventions in the ICU to treat severe anemia, which often occurs in sepsis. Several problems were documented with RBC transfusions and will be reviewed, such as infection, pulmonary complications such as TRALI and Transfusion-Associated Circulatory Overload (TACO), Transfusion-Related Immunomodulation (TRIM) and multiorgan failure, and increased mortality. Most of these complications are partially explained by volume of the unit of blood as well as pathogenic factors of stored RBCs related to 2,3 BPG concentration, inflammatory mediators, nitric oxide, ATP concentration and RBC rheology, and RBC adhesion characteristics. These same factors are present in RBCs of septic patients as well. Until better evidence is available, a “restrictive” strategy of RBC transfusion (transfuse when Hb < 7 g/dL) is recommended except in acute hemorrhage, or in patients with acute myocardial ischemia when a hemoglobin trigger of 8 g/dl is reasonable.


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