alexa Reduced High Density Lipoprotein Concentration Modulate
ISSN: 2327-5146

General Medicine: Open Access
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Research Article

Reduced High Density Lipoprotein Concentration Modulates Increased Interleukin-10 and Decreased Interferon-Gamma in Visceral Leishmaniasis Patients

Ranjeet K Paswan1, Sanjiva Bimal2, Anjali Kumari1, Preeti Sinha1, Vidya N Rabidas3, Krishna Pandey3, Sanjay Kumar1, Rakesh B Verma4, Pradeep Das5 and Chandra S Lal1*

1Division of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agam-kuan, Patna, India

2Division of Immunology, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agam-kuan, Patna, India

3Division of Medicine, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agam-kuan, Patna, India

4Division of Social Science, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agam-kuan, Patna, India

5Division of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agam-kuan, Patna, India

*Corresponding Author:
C.S.Lal
Division of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences
(Indian Council of Medical Research), Agam-kuan, Patna 800 007, India
Tel: +91 612 2634379
Fax: +91 612 2634379
E-mail: [email protected]

Received: March 9, 2016; Accepted:April 12, 2016; Published: April 19, 2016

Citation: Paswan RK, Bimal S, Kumari A, Sinha P, Rabidas VN, et al., (2016) Reduced High Density Lipoprotein Concentration Modulates Increased Interleukin-10 and Decreased Interferon-Gamma in Visceral Leishmaniasis Patients. Gen Med (Los Angel) 4:233. doi:10.4172/2327-5146.1000233

Copyright: © 2016 Paswan RK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Visceral leishmaniasis (commonly called kala-azar) is an immune-compromised parasitic protozoan disease. Hypocholesterolemia is one of the major observations in visceral leishmaniasis. The aim of this study was to evaluate and correlate total cholesterol and lipoproteins with gamma-interferon, a protective cytokine and interleukin-10, a disease progressive cytokine in visceral leishmaniasis patients. We conducted correlation studies among lipid profile, interleukin-10 and gamma-interferon on visceral leishmaniasis patients (n = 34). Lipid profile was analyzed on chemistry analyzer according to standard procedure. Gamma-interferon and interleukin-10 were analyzed quantitatively and qualitatively by enzyme linked immunosorbent assay and Fluorescence activated cell sorter respectively (n = 34). The releasing ability of interleukin-10 and gamma-interferon was assayed by fluorescence activated cell sorter (n = 10). We observed a positive correlation between total cholesterol and gamma-interferon (R = 0.364, p = 0.034) and between high density lipoprotein and gamma-interferon (R = 0.628, p = 0.0001). While negative correlation between total cholesterol and interleukin-10 (R = -0.399, p = 0.019) and between high density lipoprotein and interleukin-10 (R = - 0.526, p = 0.001) were observed. The releasing ability of interleukin-10 was increased and gamma-interferon was decreased at lower concentration of high density lipoprotein (p < 0.05). Thus, the present work suggests the correlation of total serum cholesterol and high density lipoprotein with gammainterferon and interleukin-10 release in protection and disease progression respectively in visceral leishmaniasis.

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