Reduced High Density Lipoprotein Concentration Modulates Increased Interleukin-10 and Decreased Interferon-Gamma in Visceral Leishmaniasis Patients
- *Corresponding Author:
Division of Biochemistry, Rajendra Memorial Research Institute of Medical Sciences
(Indian Council of Medical Research), Agam-kuan, Patna 800 007, India
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Received: March 9, 2016; Accepted:April 12, 2016; Published: April 19, 2016
Citation: Paswan RK, Bimal S, Kumari A, Sinha P, Rabidas VN, et al., (2016) Reduced High Density Lipoprotein Concentration Modulates Increased Interleukin-10 and Decreased Interferon-Gamma in Visceral Leishmaniasis Patients. Gen Med (Los Angel) 4:233. doi:10.4172/2327-5146.1000233
Copyright: © 2016 Paswan RK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visceral leishmaniasis (commonly called kala-azar) is an immune-compromised parasitic protozoan disease. Hypocholesterolemia is one of the major observations in visceral leishmaniasis. The aim of this study was to evaluate and correlate total cholesterol and lipoproteins with gamma-interferon, a protective cytokine and interleukin-10, a disease progressive cytokine in visceral leishmaniasis patients. We conducted correlation studies among lipid profile, interleukin-10 and gamma-interferon on visceral leishmaniasis patients (n = 34). Lipid profile was analyzed on chemistry analyzer according to standard procedure. Gamma-interferon and interleukin-10 were analyzed quantitatively and qualitatively by enzyme linked immunosorbent assay and Fluorescence activated cell sorter respectively (n = 34). The releasing ability of interleukin-10 and gamma-interferon was assayed by fluorescence activated cell sorter (n = 10). We observed a positive correlation between total cholesterol and gamma-interferon (R = 0.364, p = 0.034) and between high density lipoprotein and gamma-interferon (R = 0.628, p = 0.0001). While negative correlation between total cholesterol and interleukin-10 (R = -0.399, p = 0.019) and between high density lipoprotein and interleukin-10 (R = - 0.526, p = 0.001) were observed. The releasing ability of interleukin-10 was increased and gamma-interferon was decreased at lower concentration of high density lipoprotein (p < 0.05). Thus, the present work suggests the correlation of total serum cholesterol and high density lipoprotein with gammainterferon and interleukin-10 release in protection and disease progression respectively in visceral leishmaniasis.