alexa Reduced Hospital Stay in Influenza Patients after Mass Vaccination during the 2009 Influenza Pandemic in Norway | OMICS International | Abstract
ISSN: 2157-7560

Journal of Vaccines & Vaccination
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Research Article

Reduced Hospital Stay in Influenza Patients after Mass Vaccination during the 2009 Influenza Pandemic in Norway

Kristin Greve-Isdahl Mohn1,2*, Birger N Lærum1, Steinar Skrede1,3, Rebecca J Cox2,4, Anne Ma Dyrhol-Riise1,3, Hans Erling Simonsen1, Nina Langeland1,3, Jörg Aβmus5, Per-Espen Akselsen1,4, Haakon Sjursen1,3 and Ingrid Smith1,4

1Infectious Diseases Unit, Department of Internal Medicine, Haukeland University Hospital, N-5021 Bergen, Norway

2Influenza Centre and Jebsen Centre for Influenza vaccine research, Department of Clinical Sciences, University of Bergen, N-5021 Bergen, Norway

3Department of Clinical Sciences, University of Bergen, N-5021 Bergen, Norway

4Department of Research and Development, Centre of Infection Control, Haukeland University Hospital, N-5021 Bergen, Norway

5Department of Research and Development, Centre for Clinical Research, Haukeland University Hospital, N-5021 Bergen, Norway

*Corresponding Author:
Kristin Greve-Isdahl Mohn
Infectious Diseases Unit, Department of Internal Medicine
Haukeland University Hospital, N-5021 Bergen
Norway. Influenza Centre, Clinical Institute of Medicine
University of Bergen, N-5021 Bergen, Norway
Tel: +47 55 97 58 00/+47 97 77 07 55
E-mail: [email protected]

Received date: June 26, 2013; Accepted date: August 20, 2013; Published date: August 23, 2013

Citation: Mohn KGI, Lærum BN, Skrede S, Cox R, Dyrhol-Riise AM, et al. (2013) Reduced Hospital Stay in Influenza Patients after Mass Vaccination during the 2009 Influenza Pandemic in Norway. J Vaccines Vaccin 4:197. doi: 10.4172/2157-7560.1000197

Copyright: © 2013 Mohn KGI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Norway had a pre-order of vaccine, when the pandemic influenza A (H1N1)pdm09 in 2009 was declared. Mass vaccination occurred 1-3 weeks prior to the peak of the pandemic. Emergency plans were in place, but the predicted severe numbers of hospitalizations did not occur. Objective: To study the epidemiology and clinical presentation of adult patients hospitalized with influenza A (H1N1) pdm09, and to evaluate the impact of vaccination on the course of the pandemic at a tertiary hospital. Methods: The low dose oil-in-water adjuvanated vaccine was used to vaccinate healthcare workers (HCWs) and at risk patients groups, and vaccination rates were recorded for the community and the hospital. Demographic and clinical information was obtained for 129 patients (>15 years), hospitalized with influenza A (H1N1)pdm09 between August 2009-January 2010. A confirmed case of influenza A (H1N1)pdm09 was defined as meeting a clinical case definition and/or laboratory confirmed disease (rt-PCR or serology). Hospital stay of more than 2 days was defined as a sign of severe illness. Results: 1/3 of at risk patients in the community and >90% of frontline HCWs at the hospital were vaccinated. The median length of hospital stay of infected patients was significantly reduced 7 days after the onset of mass vaccination (p=0.029). There was a predominance of female and moderately obese (BMI 25-30) patients. Infiltration on chest X-ray upon admission was significantly associated with a hospital stay of >2 days (p=0.001). Conclusion: Mass vaccination of frontline HCWs at the hospital and at risk patients in the community contributed to the observed significant reduction in hospital stay of patients infected with influenza. Almost no absenteeism enabled staff confidence and the ability for quick and safe patient turnover. This study highlights the importance of early influenza vaccination, to protect the high-risk patients and the integrity of the healthcare system.

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