alexa Reduced NGF-Serum Concentrations in Coronary Artery Disease Patients Increase after Coronary Artery Bypass Grafting | OMICS International | Abstract
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Reduced NGF-Serum Concentrations in Coronary Artery Disease Patients Increase after Coronary Artery Bypass Grafting

Stephan Köhler1*, Sems Malte Tugtekin2, Utz Kappert2, Manuel Willbring2, Sarah Eckart1, Rainer Hellweg1 and Undine E Lang3
1Department of Psychiatry and Psychotherapy, Charite Medicine Berlin, Germany
2Department of Cardiac Surgery, Heart Center Dresden, Germany
3Department of Psychiatry, University of Basel, Germany
Corresponding Author : Dr. med. Stephan Kohler
Campus Mitte
Department of Psychiatry and Psychotherapy
Charite University Medicine Berlin
Charitéplatz 1, 10117 Berlin, Germany
Tel: 0049-30-450-617195
Fax: 0049-3328-305584
E-mail: [email protected]
Received November 03, 2012; Accepted December 10, 2012; Published December 12, 2012
Citation: Kohler S, Tugtekin SM, Kappert U, Willbring M, Eckart S, et al. (2013) Reduced NGF-Serum Concentrations in Coronary Artery Disease Patients Increase after Coronary Artery Bypass Grafting. J Clin Exp Cardiolog 4:228. doi:10.4172/2155-9880.1000228
Copyright:© 2013 Kohler S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: Coronary Artery Disease (CAD) is the leading cause of death worldwide, but neurological deficits are the most devastating complications of its treatment, Coronary Artery Bypass Surgery (CABG). As Nerve Growth Factor (NGF) has been implicated in the modulation of inflammatory and fibroproliferative mechanisms leading to atherosclerosis as well as in neuroprotection and survival of neurons, the time course of NGF serum concentrations during CABG has been studied. Methods: Twenty-six male patients were scheduled for coronary artery bypass grafting and NGF levels have been measured 1 hour before the operation started and 2, 5 and 120 hours postoperatively. Pre-operation values of NGFs were compared to healthy controls. Results: We found significantly lower NGF serum concentrations in coronary artery disease patients (n=26, age: 68.8 ± 5.5 years, mean NGF: 13.04 ± 32.1 pg/ml) as compared to age-matched healthy controls (n=20, age: 64.35 ± 4.15, mean NGF: 29.54 ± 24.23 pg/ml). A significant increase of NGF was found 120 hours after operation (Z=3.26, p=0.001). Conclusion: NGF seems to be decreased in coronary artery disease and is increased by operative coronary revascularization procedures. Changes occurring during cardiac surgery may indicate beneficial regenerative processes but may also implicate neuronal alterations induced by operative procedures.

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