Regenerative Potential of Intravenous Infusion with Mononuclear Cells in Cord Blood and G-CSF-Mobilized Peripheral BloodYoung-Ho Lee*
Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea
- *Corresponding Author:
- Young-Ho Lee, M.D., Ph.D
Department of Pediatrics
Hanyang University College of Medicine
#222, Wangsimni-ro, Seongdong-gu
Seoul 133-792, Republic of Korea
Tel: 82 2 2290 8383
Fax: 82 2 2297 2380
E-mail: [email protected]
Received date: May 26, 2014; Accepted date: August 04, 2014; Published date: August 06, 2014
Citation: Lee YH (2014) Regenerative Potential of Intravenous Infusion with Mononuclear Cells in Cord Blood and G-CSF-Mobilized Peripheral Blood. J Stem Cell Res Ther 4:224. doi:10.4172/2157-7633.1000224
Copyright: © 2014 Lee YH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Up to now most of the cells used in cell therapeutics have been mesenchymal stem cells (MSCs). However, mononuclear cells (MNCs) from cord blood (CB) or G-CSF (granulocyte-colony stimulating factor)-mobilized peripheral blood (mPB) MNCs could be an alternative option because MNCs contain both HSCs (hematopoietic stem cells) and MSCs. In addition, cellular components other than purified HSCs or MSCs could play important roles in tissue regeneration. The optimal route of administration in cell therapy is another important issue. The therapeutic benefits and clinical availability of intravenous infusion of CB- or mPB-MNCs in the field of cell therapy will be briefly reviewed.