alexa Regulating DCs in Innate Immune Response and Infection
ISSN 2476-1966

Journal of Immunobiology
Open Access

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Review Article

Regulating DCs in Innate Immune Response and Infection by Cytoskeletal Proteins

Wei Lin1* and Xin Wang2*

1Department of Microbiology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250032, PR China

2Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, Shandong 250012, PR China

*Corresponding Authors:
Wei Lin Ph.D.
Department of Microbiology, Shandong Academy of Medical Sciences
18877 Jingshi Road, Jinan, Shandong 250030, PR China
Tel: 8615098926353
E-mail: [email protected]
 
Xin Wang Ph.D.
Department of Clinical Laboratory, Qilu Hospital
Shandong University, Jinan, Shandong Province 250012, PR China
E-mail: [email protected]

Received date: April 23, 2017; Accepted date: May 16, 2017; Published date: May 22, 2017

Citation: Lin W, Wang X (2017) Regulating DCs in Innate Immune Response and Infection by Cytoskeletal Proteins. J Immuno Biol 2:124. doi: 10.4172/2476-1966.1000124

Copyright: © 2017 Lin W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Dendritic cells (DCs) are important antigen-presenting cells of innate immune system. Their main function is to take up antigen and present it to T-cells to active adaptive immune response. The cytoskeletal proteins of the DCs not only maintain the morphology of DCs, but also are associated with the maturation and function of DCs. Additionally, rearrangement of cytoskeletal proteins is associated with viral infection in DCs. Regulating the specific cytoskeletal proteins of DCs would be a potential therapeutic strategy for preventing viral infection. Thus, the role of cytoskeletal proteins of DCs in immune response and viral infections were reviewed.

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