alexa Regulation of Mirna Pathway and Roles of Micrornas in Tumorigenesis and Metastasis
ISSN: 2161-0436

Human Genetics & Embryology
Open Access

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Review Article

Regulation of Mirna Pathway and Roles of Micrornas in Tumorigenesis and Metastasis

Rong Jiang and Yujing Li*
Department of Human Genetics, Emory University School of Medicine, 615 Michael St, Atlanta, GA 30322, USA
Corresponding Author : Yujing Li
Department of Human Genetics
Emory University School of Medicine
615 Michael St, Atlanta, GA 30322, USA
E-mail: [email protected]
Received January 23, 2013; Accepted February 04, 2013; Published February 06, 2013
Citation: Jiang R, Li Y (2013) Regulation of Mirna Pathway and Roles of Micrornas in Tumorigenesis and Metastasis. Human Genet Embryol S2:007. doi: 10.4172/2161-0436.S2-007
Copyright: © 2013 Jiang R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Although small non-coding RNAs, particularly microRNAs (miRNAs), small interference RNAs (siRNAs), and piwiinteracting RNAs (piRNAs), account for only a minor fraction of the expressed genome, they have been recognized as important regulators of gene and genome at post-transcriptional levels, functioning as RNA interference (RNAi) to regulate some of the most important biological processes in eukaryotic cells. Following the identification of the major components within the RNAi/miRNA pathway, some protein co-factors have been characterized to play significant roles in activity regulation of the RNAi/miRNA pathway in the last few years, suggesting that any regulators must be tightly regulated. It has been shown that microRNAs play vital roles in regulation of multiple signaling pathways and are involved in a variety of physiological and pathological processes. Given that high percentage of the identified human miRNAs-coding genes are located at tumor-related fragile chromosome regions, and that an increasing body of evidence supports the strong link between aberration of miRNA expression and malignancies, the regulatory network organizing the miRNAs, miRNA regulating factors and miRNA targets particularly the tumor suppressors or oncogenes is suggested. This review highlights the current evidence for the significance of the link of miRNAs and tumorigenesis and metastasis.

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