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Regulation of T-cell Tolerance by Lymphatic Endothelial Cells | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Regulation of T-cell Tolerance by Lymphatic Endothelial Cells

Sherin J. Rouhani, Jacob D. Eccles, Eric F. Tewalt and Victor H. Engelhard*
Carter Immunology Center and Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Corresponding Author : Victor H. Engelhard
Carter Immunology Center
University of Virginia School of Medicine
Box 801386, Charlottesville VA 22908, USA
Tel: 434-924-2423
Fax: 434-924-1221
E-mail: [email protected]
Received June 16, 2014; Accepted July 24, 2014; Published July 31, 2014
Citation: Rouhani SJ, Eccles JD, Tewalt EF, Engelhard VH (2014) Regulation of T-cell Tolerance by Lymphatic Endothelial Cells. J Clin Cell Immunol 5:242. doi: 10.4172/2155-9899.1000242
Copyright: © 2014 Rouhani SJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Lymphatic endothelial cells are most often thought of as structural cells that form the lymphatic vasculature, which transports fluid out of peripheral tissues and transports antigens and antigen presenting cells to lymph nodes. Recently, it has been shown that lymphatic endothelial cells also dynamically respond to and influence the immune response in several ways. Here, we describe how lymphatic endothelial cells induce peripheral T-cell tolerance and how this relates to tolerance induced by other types of antigen presenting cells. Furthermore, the ability of lymphatic endothelial cells to alter immune responses under steady-state or inflammatory conditions is explored, and the therapeutic potential of bypassing lymphatic endothelial cell -induced tolerance to enhance cancer immunotherapy is discussed.