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Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Review Article

Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors

Venugopal Gunda1 and Yakkanti A Sudhakar2*

1The Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA

2Cell Signaling Laboratory, Bioscience Division, Center for Cancer and Metabolism, Stanford Research Institute (SRI) International, Menlo Park, CA 94025, USA

*Corresponding Author:
Yakkanti Akul Sudhakar
Senior Scientist/Associate Director
Center for Cancer & Metabolism, Cell Signaling Laboratory
Bioscience Division, SRI International
333 Ravenswood Avenue, Menlo Park, California 94025-3493
Tel: (650) 859-3262
Fax: (650) 859-3153
E-mail: [email protected]

Received Date: June 27, 2013; Accepted Date: July 02, 2013; Published Date: July 04, 2013

Citation: Gunda V, Sudhakar YA (2013) Regulation of Tumor Angiogenesis and Choroidal Neovascularization by Endogenous Angioinhibitors. J Cancer Sci Ther 5:417-426. doi:10.4172/1948-5956.1000235

Copyright: © 2013 Gunda V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Angiogenesis is the process of neovascularization from parent blood vessels, which is a prerequisite for many physiological and pathological conditions and is regulated by a balance between endogenous angioinhibitors and angioactivators or angiogenic factors. Imbalance between angioinhibitors and angioactivators is associated with neovascularization capacity during progression of tumor development and Choroidal Neovascularization (CNV). Normalization of pathological angiogenesis is considered as an alternative strategy to prevent the tumor growth in cancer progression or retinal damage in CNV. Various angioinhibitors are being identified and evaluated for their pathological angiogenesis regulation, of which endogenous angioinhibitors are one class derived either from extra cellular matrix or from non-extra cellular matrix of human origin. Endogenous angioinhibitors are gaining much significance as they interact with proliferating endothelial cells by binding to distinct integrins and non-integrin receptors, regulating different intracellular signaling mechanisms leading to inhibition of choroidal neovascularization and tumor growth. This review will focus on endogenous angioinhibitors and their receptor(s) mediated angioinhibitory signaling, which are of major concern in angiogenesis and their clinical and pharmaceutical implications.