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Relapsing Transient Neonatal Diabetes Mellitus due to ABCC8 Mutation | OMICS International | Abstract
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Case Report

Relapsing Transient Neonatal Diabetes Mellitus due to ABCC8 Mutation

Poovazhagi V* and Thangavelu S

Thanjavur Medical College, Department of Pedaitrics, Govt Raja Mirasdar Hospital, Anna Salai, Thanjavur, TamilNadu, India

*Corresponding Author:
Poovazhagi V
Associate professor of pediatrics
Thanjavur Medical College
Department of Pedaitrics
Govt Raja Mirasdar Hospital
Anna Salai, Thanjavur, TamilNadu, India
Tel: 044-9840033020
E-mail: [email protected]

Received Date: September 03, 2014; Accepted Date: October 06, 2014; Published Date: October 15, 2014

Citation: Poovazhagi V, Thangavelu S (2014) Relapsing Transient Neonatal Diabetes Mellitus due to ABCC8 Mutation. J Mol Genet Med 8:136. doi:10.4172/1747-0862.1000136

Copyright: © 2014 Poovazhagi V, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Neonatal diabetes mellitus with onset in the first six months of life is predominantly monogenic. Genetic evaluation of such infants is mandatory irrespective of the diabetic duration. Management of sulphonylurea responsive mutation induced diabetes is rewarding as it improves the metabolic control without exogenous insulin lifelong. Here we present a child with neonatal onset diabetes who remitted at 10 months of age and relapsed at 10 years, 8 months of age and was effectively switched over to oral sulphonylurea following identification of mutation in the ABCC8- SUR1 subunit of the K-ATP channel.

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