alexa Relationship between EEG Alpha3/Alpha2 Ratio and the Nucleus Accumbens in Subjects with Mild Cognitive Impairment
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Relationship between EEG Alpha3/Alpha2 Ratio and the Nucleus Accumbens in Subjects with Mild Cognitive Impairment

Moretti DV *, Paternicò D, Binetti G, Zanetti O and Frisoni GB

IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy

Corresponding Author:
Vito Davide Moretti
IRCCS ‘San Giovanni di Dio – FBF’
Brescia; Italy
Tel: +390303501597
Fax: +390303533513
E-mail: [email protected]

Received date: February 08, 2013; Accepted date: March 30, 2013; Published date: April 09, 2013

Citation: Moretti DV, Paternicò D, Binetti G, Zanetti O, Frisoni GB (2013) Relationship between EEG Alpha3/Alpha2 Ratio and the Nucleus Accumbens in Subjects with Mild Cognitive Impairment. J Neurol Neurophysiol 4:149. doi:10.4172/2155-9562.1000149

Copyright: © 2013 Moretti DV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: The nucleus accumbens (NAc) has been associated with impulsive behavior in subjects with
early cognitive impairment; grey matter (GM) changes of basal ganglia have been demonstrated to be involved
in Alzheimer’s disease (AD). Moreover, the increase of EEG alpha3/alpha2 ratio has been associated with ADconverters
subjects with mild cognitive impairment (MCI).
Objective: To study the association of EEG marker with specific GM changes of NAc in subjects with MCI
Methods: 74 adult subjects with mild cognitive impairment underwent EEG recording and high resolution 3D
magnetic resonance imaging (MRI). The alpha3/alpha2 ratio was computed for each subject. Three groups were
obtained according to increasing tertiles values of alpha3/alpha2. Grey matter density differences between groups
were investigated using a Voxel Based Morphometry technique.
Results: Subjects with lower a3/a2 and middle a3/a2 ratio ratio showed greater gray matter reduction in the NAc
bilaterally when compared to subjects with higher a3/a2 ratio.
Conclusion: The a3/a2 ratio was associated with increase of grey matter density inside the NAc in MCI subjects
at major risk to develop AD.


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