Relationship between Framingham Risk Score and Left Ventricular Remodeling after Successful Primary Percutaneous Coronary Intervention in Patients with First Myocardial Infarction and Single-Vessel Disease
|Marlon A.G.M. Olimulder1, Michel A. Galjee1, Jan van Es1, Lodewijk J. Wagenaar1, Martin G. Stoel1, Gert K. van Houwelingen1, J. (Hans) W. Louwerenburg1, Frits H.A.F. de Man1, Job van der Palen2,3 and Clemens von Birgelen1,4*|
|1Department of Cardiology, Thoraxcentrum Twente, MST, The Netherland|
|2Department of Epidemiology, University of Twente, The Netherland|
|3Department of Research Methodology, Measurement & Data Analysis, University of Twente, The Netherland|
|4Department of Health Technology and Services Research, MIRA – Institute for Biomedical Technology & Technical Medicine, University of Twente, Enschede, The Netherlands|
|Corresponding Author :||C. von Birgelen
MD PhD FESC, Thoraxcentrum Twente
Department of Cardiology, MST, Haaksbergerstraat 55
7513 ER Enschede, The Netherlands
E-mail: [email protected]
|Received February 26, 2013; Accepted April 03, 2013; Published April 05, 2013|
|Citation: Olimulder MAGM, Galjee MA, van Es J, Wagenaar LJ, Stoel MG, et al. (2013) Relationship between Framingham Risk Score and Left Ventricular Remodeling after Successful Primary Percutaneous Coronary Intervention in Patients with First Myocardial Infarction and Single-Vessel Disease. J Clin Exp Cardiolog 4:241. doi:10.4172/2155-9880.1000241|
|Copyright: © 2013 Olimulder MAGM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: Limited data is available on the potential value of estimated cardiovascular event risk for prediction of left ventricular (LV) remodeling and size of infarcted tissue after ST-elevation myocardial infarction (STEMI).
Methods: Therefore, we assessed in a consecutive series of patients with first STEMI, successful primary percutaneous coronary intervention (PCI), and single-vessel disease the potential relationship between the Framingham Risk Score and parameters of both LV remodeling and infarct tissue characteristics, as determined with contrast-enhanced (CE) cardiovascular magnetic resonance (CMR) 6 months after the index event. Parameters of LV remodeling were end-diastolic and end-systolic volumes, ejection fraction, and wall motion score index; infarct tissue characteristics comprised core, peri, and total infarct size, and transmural extent.
Results: A total of 25 patients (21 men, 56 ± 10 years) were studied, and the mean Framingham Risk Score was 14.1 ± 5.8%. There was a significant relation between Framingham Risk Score and multiple parameters of LV remodeling: LV ejection fraction, end-diastolic volume, end-systolic volume, and wall motion score index after 6 months (r=-0.55-0.76; p=0.000 for all). Framingham Risk Score showed no relation with various infarct tissue characteristics (ns). Male gender was the only component of the Framingham Risk Score that correlated individually with a few parameters of LV remodeling: LV end-diastolic volume and end-systolic volume (p=0.000 for both).
Conclusion: In a series of consecutive patients with first STEMI, successful primary PCI, and single-vessel coronary artery disease, we observed a significant relation between the Framingham Risk Score and several CMRbased parameters of LV remodeling.
The results of our small hypothesis-generating study underline the supremacy of multifactorial risk scores as tools for prediction of unfavorable cardiovascular outcome. Additionally, the data support the hypothesis that there might be a future role for a novel and specific multifactorial risk score in predicting unfavorable LV remodeling, which finally could trigger risk-adjusted preventive measures.