Relationship between Lung Functions and Extend of Emphysema in Patients with Chronic Obstructive Pulmonary DiseaseMuzaffer Sariaydin, Nejat Altintas* and Ozgur ince
Namik Kemal University, School of Medicine, Department of Pulmonary Medicine, Tekirdag, Turkey
- *Corresponding Author:
- Nejat Altintas
Namik Kemal University, School of Medicine
Department of Pulmonary Medicine, Tekirdag, Turkey
Email: [email protected]
Received date: May 12, 2014; Accepted date: June 24, 2014; Published date: June 27, 2014
Citation: Sariaydin M, Altintas N, Ozgurince (4) Relationship between Lung Functions and Extend of Emphysema in Patients with Chronic Obstructive Pulmonary Disease. J Pulm Respir Med 4:191. doi:10.4172/2161-105X.1000191
Copyright: © 2014 Rotsinger JE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: To investigate whether the extent of emphysema, visually confirmed by high resolution computed tomography (HRCT) in patients with COPD were associated with different indices of lung functions.
Methods: Eighty-two patients with COPD underwent HRCT scanning; visual assessment of HRCT scan was used in the calculation of extent of emphysematous
Destruction: The patients were clinically stable at the time of the evaluation. All subjects were smokers or past smokers who had smoked>10 pack-years.
Results: The mean visual emphysema score in all patients was 2.21 ± 1.11. While the mean emphysema score in patients with COPD GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage 3 was 2.88 ± 1.03, it was 1.54 ± 1.16 in COPD GOLD stage 2 (p<0.001). There was a significant correlation between the emphysema score and the numbers of pack/years smoked (R=0.58, p<0.001). The visual emphysema score was inversely correlated with the FEV1(r =-0.56, p<0.0001), FVC (r=-0.38, p=0.001), FEV1/FVC (r=-0.43, p<0.001), PEF(r=-0.44, p<0,001) and with the Carbon monoxide diffusing capacity divided by the alveolar volume (DLCO/VA) (r=-0.50, p<0.001). In our study population, patients had a limited expression of the disease as represented by low scores in Saint George Respiratory Questionnaire (SGRQ), and there was no correlation between emphysema score and SGRQ.
Conclusions: HRCT visual scores correlated with functional indices of airflow obstruction and impaired lung diffusing capacity in patients with stable COPD of varying severity, the presence of pulmonary emphysemais best represented by the FEV1 and DLCO/VA.