alexa Relationship between the Status of Blood Supply in the
ISSN: 2167-0889

Journal of Liver
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Research Article

Relationship between the Status of Blood Supply in the Non-hypervascular Hepatocellular Nodules among Chronic Liver Diseases and the Hypervascular Change

Junichi Taira1, Yasuharu Imai1*, Takatomo Sano2, Katsutoshi Sugimoto2, Yoshihiro Furuichi2, Ikuo Nakamura2, Fuminori Moriyasu2

1Department of Gastroenterology and Hepatology, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji City, Tokyo 193-0998, Japan

2Department of Gastroenterology and Hepatology, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan

*Corresponding Author:
Yasuharu Imai
Department of Gastroenterology and Hepatology
Tokyo Medical University Hachioji Medical Center
1163 Tatemachi, Hachioji City, Tokyo 193-0998, Japan
Tel: 81-42-665-5611
E-mail: [email protected]

Received date: June 14, 2016; Accepted date: July 19, 2016; Published date: July 28, 2016

Citation: Taira J, Imai Y, Sano T, Sugimoto K, Furuichi Y, et al. (2016) Relationship between the Status of Blood Supply in the Non-hypervascular Hepatocellular Nodules among Chronic Liver Diseases and the Hypervascular Change. J Liver 5:197. doi:10.4172/2167-0889.1000197

Copyright: © 2016 Taira J et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objectives: We observed the time-course changes of blood flow in non-hypervascular hepatocellular nodules that showed hypointensity in the hepatobiliary phase on Gd-EOB-DTPA-enhanced magnetic resonance imaging (EOB-MRI), and evaluated the relationship between hypervascular change and the status of blood supply in the nodules. Methods: The study included 69 hepatocellular nodules in 33 patients demonstrating hypointensity in the hepatobiliary phase on EOB-MRI and showing non-hypervascular features on CT during hepatic arteriography (CTHA) performed during the same period. Results: In relation to blood flow on CTHA/ CT during arterial portography (CTAP), the cumulative rate of hypervascular change at 52 weeks was 0.0% for iso/iso, 29.7% for hypo/iso, 61.5% for iso/hypo, and 55.0% for hypo/hypo. Multivariate analysis using COX proportional hazards regression showed that CTAP findings (hypodensity) and CTHA findings (hypo-density) were significant variables for hypervascular change. Conclusions: In cases of non-hypervascular hepatocellular tumors, nodules with decreased arterial or portal blood flow that show hypointensity in the hepatobiliary phase on EOB-MRI are likely to develop into typical hepatocellular carcinoma in a shorter time.

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