Relationship between Uric Acid and Endothelial Function in Hypertensive Patients with Metabolic Syndrome
|Xiaodong Huang1, Xiaoqi Cai2, Wuhong Zheng2, Yihua Shen2 and Liangdi Xie2*|
|1The First Hospital of Nanping City, Fujian Medical University, 317 Zhongshan Road, Naping City, PR China|
|2Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou City, PR China|
|Corresponding Author :||Liangdi Xie
Fujian Hypertension Research Institute
The First Affiliated Hospital of Fujian Medical University
20 Chazhong Road, Fuzhou City
PR China, Postal Code: 350005
E-mail: [email protected]
|Received: November 27, 2015 Accepted: February 08, 2016 Published: February 18, 2016|
|Citation: Huang X, Cai X, Zheng W, Shen Y and Xie L (2016) Relationship between Uric Acid and Endothelial Function in Hypertensive Patients with Metabolic Syndrome. J Clin Exp Cardiolog 7:416. doi:10.4172/2155-9880.1000416|
|Copyright: © 2016 Huang X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Aim: To investigate the association between uric acid (UA) and endothelial function in Chinese hypertensive patients with Metabolic Syndrome (MS).
Methods: 615 hypertensive patients were enrolled, all hypertensives were divided into two groups: hypertensives with MS (MS group, n=239) and hypertensives without MS (NMS group, n=376). 87 age- and sex-matched normotensives served as controls (NC group). Flow-mediated (endothelium-dependent) dilatations (FMD), nitroglycerin-induced (endothelium-independent) dilatation (EID) in the brachial artery were assessed by highresolution ultrasonography. UA was detected by urease indophenol.
Results: A trend of increase in UA concentration was found among NC, NMS and MS group ((323.77 ± 104.49) μmol/l vs. (353.63 ± 92.83) μmol/l vs. (390.90 ± 101.42) μmol/l, p<0.001). There was a significant difference in FMD (control: (12.03 ± 4.51)% vs. NMS:(8.98 ± 4.32)% vs. MS:(8.23 ± 4.58)%, p<0.001) among groups. After stratification of gender, lower FMD was only seen in male hypertensives with MS accompanied by hyperuricemia <60 years old ((9.98 ± 5.78)% vs (7.12 ± 4.49)%, p<0.05); Pearson correlation analysis showed that the FMD was negatively correlated with UA (r=-0.314, p<0.01); Finally, logistic regression analysis showed that a 50 μmol/L increase in UA levels carried a 41.1% higher risk for endothelial dysfunction in this cohort.
Conclusions: A higher UA level is related to poorer endothelial function in hypertensives with MS. Increased UA can be used as an alternative indicator for monitoring endothelial function and preventing vascular damage in male hypertensives with MS aged less than 60 years old.