Relationships of A1c Variability for 10 Years and Beta Cell Function at the Time of Diagnosis in Type 2 Diabetes
|Eun Ju Lee, Mi-Kyung Kim*|
|Department of Internal Medicine, College of Medicine, Inje University, Republic of Korea|
|Corresponding Author :||Mi-kyung Kim, M.D., Ph.D
Associate professor, Chair
Endocrinology Diabetes and Metabolism
Internal Medicine, Haeundae Paik Hospital
College of Medicine
Inje University, 875
Hauendae-ro, Hauendae-gu, Busan
612-862, Republic of Korea
Tel: 82 517970636
E-mail: [email protected]
|Received March 16, 2015; Accepted April 13, 2015; Published April 20, 2015|
|Citation: Lee EJ, Park JI, Kim TN, Kim TK, Kwon MJ, et al. (2015) Relationships of A1c Variability for 10 Years and Beta Cell Function at the Time of Diagnosis in Type 2 Diabetes. Gen Med (Los Angel) 3:177. doi: 10.4172/2327-5146.1000177|
|Copyright: © 2015 Lee EJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Background: Recent several reports emphasized A1c variability along with average blood glucose determined by Alc. Many studies have been showing the relationship of A1c variability with chronic diabetic complications. But, associations between patterns or degrees of A1c variability and influential factors have not been studied much. Therefore, this study aimed to evaluate the relationships of A1c variability for 10 years and beta cell function at the time of diagnosis in type 2 diabetes in clinical practice.
Methods: Subjects of this study were 518 newly diagnosed type 2 diabetic patients. To evaluate beta cell
function, we checked fasting c-peptide, glucose, and insulin and assessed homeostasis model assessment beta cell function index (HOMA-β) and homeostasis model assessment for insulin resistance (HOMA-IR) at the time of diagnosis. A1cs, fasting plasma glucose, and lipid profile were serially measured at least once in every year for 10 years.
Results: We found that higher A1c variability was associated with younger age at diagnosis of diabetes, lower BMI, higher first A1c, higher 2nd year A1c, and higher mean A1c. C-peptide and homeostasis model assessment beta cell function index were the highest in the low SD group and the lowest in high SD group.
Conclusion: A1c variability for 10 years in newly diagnosed type 2 diabetes is inversely related with the marker of beta cell function at the time of diagnosis.