alexa Relief and Resolution of Fibromyalgia Symptoms with Low Dose Methotrexate- The Origin of Pain is Inflammation and the Inflammatory Response | OMICS International | Abstract
ISSN: 2161-1149

Rheumatology: Current Research
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Research Article

Relief and Resolution of Fibromyalgia Symptoms with Low Dose Methotrexate- The Origin of Pain is Inflammation and the Inflammatory Response

Sota Omoigui*, Akinkunle Fadare and Chiedu Ogbechie

Division of Inflammation and Pain Research, L.A. Pain Clinic, Hawthorne, California, USA

*Corresponding Author:
Sota Omoigui
L.A. Pain Clinic, 4019 W. Rosecrans Ave
Hawthorne, California 90250, USA
Tel: (310) 675 9121
Fax: (310) 675 7989
E-mail: [email protected]

Received date: October 28, 2013; Accepted date: January 08, 2014; Published date: January 16, 2014

Citation: Omoigui S, Fadare A, Ogbechie C (2014) Relief and Resolution of Fibromyalgia Symptoms with Low Dose Methotrexate – The Origin of Pain is Inflammation and the Inflammatory Response. Rheumatology 4:129. doi: 10.4172/2161-1149.1000129

Copyright: © 2014 Omoigui S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Methotrexate is a Disease Modifying Anti Rheumatic Drug (DMARD) we used in the treatment of patients with severe fibromyalgia symptoms. We present two case discussions of low dose methotrexate treatment resulting in dramatic relief of widespread body pain in patients diagnosed with fibromyalgia. These patients had been refractory to prior treatment with opioids, NSAIDs, anti-seizure medications, anti-depressant medications, pregabalin and corticosteroids. Our case reports endorse Sota Omoigui’s theory of pain which states that the origin of all pain is inflammation and the inflammatory response. Low dose methotrexate has unique broad spectrum anti-inflammatory activity that is not found in any other medication. The drug may significantly decrease or resolve generalized body pain associated with fibromyalgia. The use of low dose Methotrexate co-administered with folic acid should be considered as an adjunct to pain medication to help decrease and sometimes eliminate pain and improve other symptoms such as fatigue and disability in fibromyalgia. Limiting factors include the ability of patients to tolerate the medication

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