alexa
Reach Us +44 1704 335730
Remodelling Metabolic Syndrome Components to Adapt them to the Tunisian Context and to Determine a Sole Metric Criterion | OMICS International | Abstract
ISSN: 2167-0943

Journal of Metabolic Syndrome
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article

Remodelling Metabolic Syndrome Components to Adapt them to the Tunisian Context and to Determine a Sole Metric Criterion

Sarraj Mohamed Youssef1*, Najah Mohamed1, Slimani Afef1, Ben Hamda Khaldoun3, Neffati Fadoua2, Najjar Mohamed Fadhel2 and Slimane Mohamed Naceur1
1Research Unit genetic and biological factors of atherosclerosis. Medicine Faculty, University of Monastir, Tunisia
2Laboratory of Biochemistry and Toxicology of the Fatouma Bourguiba University Hospital of Monastir, Tunisia
3Department of Cardiology of the Fatouma Bourguiba University Hospital of Monastir, Tunisia
Corresponding Author : Sarraj Mohamed Youssef
Research Unit 05/UR/09- 12: Genetic and Biological Factors of Atherosclerosis
Medicine Faculty, University of Monastir, Tunisia
Tel: 216-73-462 200
Fax: 216-73-460-737
E-mail: [email protected]
Received April 28, 2013; Accepted May 13, 2013; Published May 15, 2013
Citation: Youssef SM, Mohamed N, Afef S, Khaldoun BH, Fadoua N, et al. (2013) Remodelling Metabolic Syndrome Components to Adapt them to the Tunisian Context and to Determine a Sole Metric Criterion. J Metabolic Synd 2:121. doi:10.4172/2167-0943.1000121
Copyright: © 2013 Youssef SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aims: Metabolic Syndrome (MS) is a heterogenic entity and its major limitation was the use of binary components and the dependence of some criteria to ethnic origin and/or gender. We seek to remodel MS criteria to adapt them to the Tunisian context and to determine a sole quantitative MS parameter.

Materials and methods: 592 subjects who underwent routine control were investigated for biochemical, anthropometric and clinical examination. The diagnosis of MS was based on the IDF and AHA/NHLBI definition.The computer model HOMA 2 was used to determine HOMA-β, HOMA-S and HOMA-IR. Triglycerides (TG), High Density Lipoprotein cholesterol (cHDL), Systolic Blood Pressure (SBP), HOMA-IR and Waist Circumference Stature (WCS) were used to calculate the different MS markers. The area under curve of ROC curves were used to compare the powers of these MS parameters.

Results: HOMA-IR was more informative about glycaemia abnormality, WCS express better android obesity, and TG/cHDL ratio characterizes dyslipidemia. (TG x WCS x HOMA-IR x SBP) / cHDL parameter was more accurate to estimate MS occurrence; its cut-off point is 106.75

Conclusion: This marker, with sensitivity and specificity of 94.4 and 85.1 per cent, can be used either to diagnose or to predict MS occurrence.

Keywords

Leave Your Message 24x7
Top