Renal Disfunction in Chagas Disease
- *Corresponding Author:
- Camila Botelho Miguel
Pós-Graduação em Ciências da Saúde
Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil
Tel: +55 34 99667-7248
E-mail: [email protected]
Received date: July 27, 2017; Accepted date: August 07, 2017; Published date: August 11, 2017
Citation: Miguel CB, Rodrigues WF, Filho DM, Mendes NS, Ribeiro PDC, et al. (2017) Renal Disfunction in Chagas Disease. J Bacteriol Parasitol 8:313. doi:10.4172/2155-9597.1000313
Copyright: © 2017 Miguel CB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Chagas’ disease has a wide distribution in South America, having several forms of transmission. The disease’s evolution varies according to the parasite/host relationship, presenting diversified progression through the acute, indeterminate and chronic forms. In the cardiac form, there are several clinical and laboratory alterations due to the involvement of several organs, including the kidneys. Actually, a lot of mechanisms are employed for the control and detection of renal damage. It has been proven that before the cardiac inflammatory changes were established, alterations in renal function could be observed due to elevated levels of urea, creatinine and other alterations compatible with the clinical picture of uremia. As well it was possible to verify an anemic state in laboratory animals, thus, it could be a condition known as cardio-anemic-renal syndrome described in patients with heart failure. Although there are studies correlating clinical and laboratory findings of renal dysfunction in Chagas’ disease, there is still a need to elucidate some pathways of interaction between chagasic physiopathogeny and renal function.
Aim: The present study addresses a review of articles from the current and classical scientific literature, correlating the function and/or loss of renal function with Chagas’ disease.
Conclusion: The information base of renal pathophisyology is crucial in order to better understand this problem of public health that involves several countries and populations.