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ISSN 2155-6113

Journal of AIDS & Clinical Research
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Research Article

Renal Function Recovery and HIV Viral Suppression Following Tenofovir Discontinuation for Renal Impairment

Francine Touzard Romo1, Mariam Aziz2,3*, Britt Livak3, Emily Huesgen4, Ben Colton5, Timothy P. Flanigan1,6, Blake Max7 and Harold Kessler2,3

1The Miriam Hospital, Providence, RI, USA

2Rush University Medical Center, Chicago, IL, USA

3Cook County Health and Hospitals System, Chicago, IL, USA

4University of Illinois at Chicago, Chicago, IL, USA

5Resurrection Health Care, Chicago, IL, USA

6Brown University Medical School, Providence, RI, USA

7Ruth M. Rothstein CORE Center, Chicago, IL, USA

*Corresponding Author:
Mariam Aziz
Rush University Medical Center
Chicago, IL, USA
Tel: (312) 942-4265
E-mail: [email protected]

Received date: October 25, 2014; Accepted date: November 19, 2014; Published date: November 25, 2014

Citation: Romo FT, Aziz M, Livak B, Huesgen E, Colton B, et al. (2014) Renal Function Recovery and HIV Viral Suppression Following Tenofovir Discontinuation for Renal Impairment. J AIDS Clin Res 5:379. doi:10.4172/2155-6113.1000379

Copyright: © 2014 Romo FT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Tenofovir associated nephrotoxicity (TDFN) is well recognized. This study describes the trend of renal function recovery and virologic consequences after cessation of tenofovir (TDF) for suspected TDFN. Methods: This was a retrospective chart review of 241 patients who underwent HLA-B*5701 allele testing between January 2007-December 2010. Demographics and clinical characteristics were compared at baseline, 3, 6, and 12 month between patients that continued and discontinued TDF. Factors associated with renal function recovery were assessed by multivariable logistic regression. Results: Eighty patients were identified with TDFN; 84% male, 74% African American (AA) with a median age of 55 years, and median length of TDF use for 122 weeks. Renal recovery at 12 months differed in those who stopped versus (vs.) continued TDF (83% vs. 57% p=0.03). In a crude analysis, baseline chronic kidney disease was negatively associated with renal recovery (p=0.01). An adjusted analysis showed that those who stopped TDF had 3.76 higher odds of renal recovery compared to those who did not stop TDF (95% CI: 1.26-11.27, p=0.02). There were no significant differences in virologic response after switching TDF to an alternative agent. Conclusion: In this mostly AA male population with suspected TDFN, discontinuation of TDF was strongly associated with renal function recovery without affecting viral suppression.

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