Reproducibility and Impact of CT-Scanning on Pulse Wave Velocity Measurement for Cardiovascular Risk Stratification in an Asymptomatic PopulationThijs L Braber1,3*, Niek HJ Prakken2, Arend Mosterd3 and Birgitta K Velthuis1
- Corresponding Author:
- Thijs L Braber
Department of Radiology, University
Medical Center Utrecht, Utrecht, the Netherlands
Tel: +31 6218172109
Fax: +31 30 2581098
E-mail: [email protected]
Received date: October 31, 2015 Accepted date: February 24, 2016 Published date: February 26, 2016
Citation: Braber TL, Prakken NHJ, Mosterd A, Velthuis BK (2016) Reproducibility and Impact of CT-Scanning on Pulse Wave Velocity Measurement for Cardiovascular Risk Stratification in an Asymptomatic Population. Angiol 4:167. doi:10.4172/2329-9495.1000167
Copyright: © 2016 Braber TL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Pulse wave velocity (PWV) measurements for aortic arterial stiffness and coronary CT angiography (CCTA) may help improve cardiovascular risk assessment in asymptomatic people. On the CT-table PWV measurement is an efficient addition to the CT workflow. This study evaluated if on CT-table PWV measurements are influenced by CT anticipation stress and if the PWV measurements are reproducible.
Methods: Aortic PWV measurement reproducibility was assessed in 41 asymptomatic male sportsmen (aged 56.5 ± 6.7 years) who underwent CCTA as part of a sports medical evaluation. Three consecutive measurements were performed, two outside the CT-room for intra-observer variability followed by one on the CT-table. Pearson correlation coefficients were assessed for agreement between measurements outside the CT-room and on the CT-table. Bland-Altman analysis of limits of agreement was assessed to evaluate intra-observer variability outside the CT-room.
Results: Aortic PWV and systolic blood pressure (SBP) on the CT-table were significantly higher (+0.61 m/s, P = 0.004 and + 7 mmHg, P = 0.003 respectively), with acceptable correlation (Pearson’s correlation 0.8, R² 0.6). The Pearson’s correlation coefficients of PWV measurements outside the CT-room showed good intra-observer agreement, (Pearson’s correlation 0.9, R² 0.8) The mean re-test difference and the 95% limits of agreement outside the CT-room were fair: 0.25 m/s, 95%CI -0.99–1.51 m/s.
Conclusion: On the CT-table PWV measurements, although higher due to anticipation stress causing higher SBP, are comparable to off-table measurements at rest. The reproducibility of PWV measurements is good when done prior to a coronary CT-scan and the limits of agreement are acceptable.