alexa Reproductive Hormone Profiles during Imatinib Therapy in Men with Chronic Myeloid Leukemia | OMICS International | Abstract
ISSN: 2167-0250

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Research Article

Reproductive Hormone Profiles during Imatinib Therapy in Men with Chronic Myeloid Leukemia

Katrine Bay1*, Ole Weis Bjerrum2, Ulla Olsson-Strömberg3, Kimmo Porkka4, Inge Høgh Dufva5 and Anna-Maria Andersson1
1Department of Growth and Reproduction, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
2Department of Hematology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark
3Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
4Hematology Research Unit, Biomedicum Helsinki, Helsinki University Central Hospital, Helsinki, Finland
5Department of Hematology, University Hospital of Copenhagen, Herlev Hospital, Herlev, Denmark
*Corresponding Author : Katrine Bay
Department of Growth and Reproduction
University Hospital of Copenhagen, Copenhagen, Denmark
Tel: +45-3545-4477
Fax: +45-3545-6054
E-mail: [email protected]
Received March 16, 2013; Accepted May 08, 2013; Published May 13, 2013
Citation: Bay K, Bjerrum OW, Olsson-Strömberg U, Porkka K, Inge Dufva H (2013) Reproductive Hormone Profiles during Imatinib Therapy in Men with Chronic Myeloid Leukemia. Andrology 2:105. doi:10.4172/2167-0250.1000105
Copyright: © 2013 Bay K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Imatinib side effects related to testicular function have been reported in male patients with chronic myeloid leukemia. These include decreased testosterone levels, gynecomastia and impaired spermatogenesis. To further investigate testicular function in relation to imatinib treatment, a longitudinal study on reproductive hormone profiles was conducted in 17 male patients with chronic myeloid leukemia . Blood samples were taken before and at one or more time points during imatinib therapy. Serum samples were analyzed for the hormones testosterone, estradiol, and luteinizing hormone (LH) to reflect testicular Leydig cell function. Sex hormone-binding globulin (SHBG) serum levels were measured to evaluate free testosterone, and serum levels of inhibin B and follicle stimulating hormone were measured to reflect spermatogenesis. Out of the 17 patients included in the study, one patient developed gynecomastia after 7-10 months of therapy. Testosterone levels were generally low in the patients both before and during the study, and did not change in response to imatinib therapy. Conversely, SHBG levels decreased transiently at 3 and 6-9 months of therapy (p=0.002 and p=0.008, respectively). Estradiol levels decreased at 12-15 months of therapy (p=0.048). LH and hormones reflecting spermatogenesis were unchanged. In conclusion, our longitudinal study of men with chronic myeloid leukemia showed a significant, but largely transient, decrease in SHBG levels in response to imatinib therapy. Testosterone levels were low in the men both before and during imatinib therapy.

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