alexa Repurposing Amlexanox as a Run the Red Light Cure-All with Readthrough a No-Nonsense Approach to Personalised Medicine
ISSN: 1948-593X

Journal of Bioanalysis & Biomedicine
Open Access

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Research Article

Repurposing Amlexanox as a Run the Red Light Cure-All with Readthrough a No-Nonsense Approach to Personalised Medicine

John A Loudon*

Wetherill Park Medical Centre, Suite 101, Stockland Mall, Polding Street, Australia

*Corresponding Author:
John A Loudon
Ph.D. Cert. Oral Path., FAAOMP, BDS Hons
BSc (Dent) Hons. Syd & Ohio, Wetherill Park Medical Centre
Suite 101, Stockland Mall, Polding Street
Wetherill Park, Sydney, NSW, 2164, Australia
Tel: +61-2-9756-3636
Fax: +61-2-9756-3637
E-mail: [email protected]

Received Date: July 25, 2013; Accepted Date: August 17, 2013; Published Date: August 20, 2013

Citation: Loudon JA (2013) Repurposing Amlexanox as a ‘Run the Red Light Cure- All’ with Read-through – a ‘No-Nonsense’ Approach to Personalised Medicine. J Bioanal Biomed 5: 079-096. doi: 10.4172/1948-593X.1000086

Copyright: © 2013 Loudon JA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The burden of inherited diseases in terms of congenital defects and cancer predisposition in addition to a multitude of neurological, cardiovascular and other organ diseases arising sporadically during life is enormous on the individual, immediate family and society globally. I approach this major burden to human society by invoking the powerful technology behind read-through, whereby disease-causing substitution nonsense mutations, oftentimes at the root of human diseases, are rescued. Further, the importance of nonsense mutations in the realm of developmental factors linked to cancer stem cell maintenance is presented. The methodology behind the technique is given and proof of concept behind its use ex vivo and in clinical trials. The discovery of a novel read-through drug, Amlexanox, which has been in use for over twenty years in dentistry for oral ulcerations, represents a next generation read-through agent. This agent has been demonstrated in cell lines to correct functional loss in cystic fibrosis CFTR, dystrophin and the tumour suppressor, p53. Its novel ability to inhibit nonsense mediated decay is discussed. Amlexanox is therefore presently ready for testing in a wide variety of in vivo models of human diseases and also in clinical trials. Given the safety profile of Amlexanox and ex vivo efficacy in studies thus far it is envisaged that this accepted medication shall successfully debut as an all-purpose agent for the prevention and management of human diseases.

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