alexa Repurposing of Modified Alpidem and Propoxyphene to Cure AURKA, BCAS1, GNAS and MLH1 Gene Mutations in Colorectal Cancer
ISSN: 2169-0138

Drug Designing: Open Access
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Research Article

Repurposing of Modified Alpidem and Propoxyphene to Cure AURKA, BCAS1, GNAS and MLH1 Gene Mutations in Colorectal Cancer

Anum Munir1,2,3*, Shumaila Azam1,2,3, Sartaj Ali3, Azhar Mehmood1,3, Abbas Hussain Shah5, M Saad Khan2, Rabbiah Manzoor2,4, Maria Sana2,Shakeel Ahmed Mufti2 and Sahar Fazal2

1Bioinformatics International Research Club, Abbottabad, Pakistan

2Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan

3Department of Bioinformatics, Government Post Graduate College Mandian, Abbottabad, Pakistan

4Department of Medical Sciences, Wah Medical College, Wah Cantt, Pakistan

5Department of Botany, Government Post Graduate College Mansehra, Pakistan

*Corresponding Author:
Anum Munir
Bioinformatics International Research Club
Abbottabad, Pakistan
Tel: +923348958178
E-mail: [email protected]

Received date: December 26, 2016; Accepted date: January 22, 2017; Published date: January 30, 2017

Citation: Munir A, Azam S, Ali S, Mehmood A, Shah AH, et al. (2017) Repurposing of Modified Alpidem and Propoxyphene to Cure AURKA, BCAS1, GNAS and MLH1 Gene Mutations in Colorectal Cancer. Drug Des 6:141. doi: 10.4172/2169-0138.1000141

Copyright: © 2017 Munir A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Colorectal cancer is a varied illness with an expected heritability of 25–30%. Many CRC disorders occur because of solid family history, a high penetrance of the infection, and developing various tumors at an early age. A few novel genes are recognized that shows associations with CRC, such as AURKA, BCAS1, GNAS and MLH1. Material and methods: In this research work FDA rejected Alpidem and Propoxyphene were selected. Drugs were changed on the basis of side effects; modified drugs were docked with AURKA, BCAS1, GNAS and MLH1 proteins and QSAR analysis was performed. Results: Docked and QSAR results demonstrated the better interaction of both modified Alpidem and Propoxyphene along with proteins of CRC causing genes. The toxicity value and side-effects of modified Alpidem and modified Propoxyphene are less than original drugs. Conclusion: The fewer side effects and docking results of both modified Alpidem and Propoxyphene suggest that both the drugs can be used to cure mutations of genes in colorectal cancer as both modified drugs have fewer side-effects and toxicity, as compared to original drugs, both drugs have demonstrated greater interactions with the amino acid residues lying in the pockets of mutated proteins that demonstrates their stability and soundness.

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