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ISSN: 2167-0501

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Research Article

Research of New Molecules Able to Starve the Tumors by Molecular Docking\'s Method

Boucherit Hanane*, Chikhi Abdelouahab, Bensegueni Abderrahmane, Merzoug Amina, Hioual Khadidja Soulef and Mokrani El Hassen
Laboratory of Applied Biology and Health, Department of Biochemistry-Microbiology, Faculty of Natural And Life Sciences, Mentouri University, Constantine, Algeria
Corresponding Author : Boucherit Hanane
Laboratory of Applied Biology and Health
Department of Biochemistry-Microbiology
Faculty of Natural And Life Sciences
Mentouri University, Constantine, Algeria
Tel: +213-662-90-84-13
E-mail: [email protected]
Received May 03, 2013; Accepted June 17, 2013; Published June 20, 2013
Citation: Hanane B, Abdelouahab C, Abderrahmane B, Amina M, Soulef HK, et .(2013) Research of New Molecules Able to Starve the Tumors by Molecular Docking’s Method. Biochem Pharmacol 2:117. doi:10.4172/2167-0501.1000117
Copyright: © 2013 Hanane B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In recent years, a promising new approach uses the anti-angiogenesis properties of certain molecules to try to block cancer by depriving tumors of nutrients and oxygen they need to grow. Endothelial cells, specialized in the development of new blood vessels, are the target of most anti-angiogenic strategies, Or methionine aminopeptidase (MetAp) type 2 is a member of a family of proteins that regulates the growth of these endothelial cells. The molecular docking program, GOLD, was developed to assist in the development of molecules with therapeutic activity. It has been used to study the inhibition of 1QZY, human methionine aminopeptidase type 2, by bengamide derivatives, with the aim of discovering new anti-angiogenic drugs. The evaluation of the affinity of these molecules brought to light those presenting the best inhibitive effect. It is about the compound 16, the value of the score of which is 135.35.

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