Restorative Therapy in Stroke
Padma Srivastava MV* and Ashu Bhasin
Department of Neurology, All India Institute of Medical Sciences (AIIMS), India
- *Corresponding Author:
- Padma Srivastava MV
Professor, Department of Neurology
All India Institute of Medical Sciences (AIIMS)
New Delhi, 110029, India
E-mail: [email protected]
Received Date:August 04, 2014; Accepted Date: September 22, 2014; Published Date: September 24, 2014
Citation: Padma SMV, Ashu Bhasin (2014) Restorative Therapy in Stroke. J Transplant Technol Res 4: 136. doi: 10.4172/2161-0991.1000136
Copyright: 2014 Padma SMV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A variety of therapeutic approaches that could be considered neurorestorative are currently in clinical trials after stroke. There are essentially two varieties of restorative approaches. One is cell-based and includes stem cell transplantation with and without augmentation with growth factors and other variety is the pharmacological approach. These strategies are being explored for the ultimate aim to regain maximum restoration possible and eventual complete normalcy of function. Functional recovery post stroke may require new synaptic connections within and away from the damaged tissue. In an infracted area, the ischemic core may not respond to any pharmacological or rehabilitative intervention. For these reasons, the prospects of repairing the neuron system, using various putative restorative strategies seems promising and urgently required for further exploration, refinement and optimization. Ongoing animal and human trials have largely helped in burgeoning our hopes on this method of restorative therapy after stroke.