Results of Intensity Modulated Radiation Therapy in Patients with Well Differentiated Thyroid Carcinoma: Experience of King Fahad Medical CityMushabbab AlAsiri, Mutahir Ali Tunio*, Abdullah Amro, Shoaib Ahmad, Yasser Bayoumi and Mohsin Fareed
Radiation Oncology, Comprehensive Cancer Center, King Fahad Medical City (KFMC), Riyadh 59046, Saudi Arabia
- *Corresponding Author:
- Mutahir Tunio
MBBS, FCPS, Assistant Consultant
Radiation Oncology, Comprehensive Cancer Center
King Fahad Medical City (KFMC)
Riyadh 59046, Saudi Arabia
Tel: +966 1 2889999
Fax: 966 1 4614006
E-mail: [email protected]
Received date: May 09, 2012; Accepted date: June 08, 2012; Published date: June 12, 2012
Citation: AlAsiri M, Tunio MA, Amro A, Ahmad S, Bayoumi Y et al. (2012) Results of Intensity Modulated Radiation Therapy in Patients with Well Differentiated Thyroid Carcinoma: Experience of King Fahad Medical City. J Nucl Med Radiat Ther S6:001. doi:10.4172/2155-9619.S6-001
Copyright: © 2012 AlAsiri M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: We aimed to evaluate the outcomes and toxicity profile in patients with well differentiated thyroid carcinoma (WDTC) treated with intensity modulated radiation therapy (IMRT). Materials and methods: Between June 2007 and July 2011, 18 patients with WDTC received postoperative IMRT with mean radiation dose 66Gy (60-66) delivered with 7 dynamic beams. Median age was 50.5 years (23-66); of whom 10 were males (55.6%) and 8 were females (44.4%). Predominant histology was papillary in 17 patients (94.4%) and predominant T stage was T4 in 15 patients (83.3%). RAI therapy was given to all patients. Results: Median follow up was 53 months (6-55). At 48 months, the Kaplan-Meier estimates of locoregional control, distant control and overall survival were 88.9%, 83.2% and 89.4% respectively. Incomplete surgery, presence of lymphovascular invasion (LVI), and number of >4 positive lymph nodes were found as poor prognostic factors (0.0001). Acute grade 3 Mucositis was experienced in one patient (5.5%) and grade 3 skin toxicity was seen in 1 patient (5.5%). Late toxicities were few and of grade 2. Conclusion: Postoperative IMRT offers excellent locoregional and distant control rates and overall survival with minimal toxicity profile in the treatment of WDTC.