alexa Rethinking Demethylating Agents in Epigenetic Cancer Therapy
ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research
Open Access

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Letter to Editor

Rethinking Demethylating Agents in Epigenetic Cancer Therapy

Fides D Lay1* and Gangning Liang2*

1Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA

2Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA

Corresponding Author:
Lay FD
Department of Molecular Cell and Developmental Biology
University of California, Los Angeles, CA 90024
Tel: 310-825-710
E-mail: [email protected]
Liang G
Department of Urology, Norris Comprehensive Cancer Center
Keck School of Medicine, University of Southern California
Los Angeles, CA 90033
Tel: 323-442-1609
E-mail: [email protected]

Received Date: June 08, 2016; Accepted Date: June 23, 2016; Published Date: June 27, 2016

Citation: Lay FD, Liang G (2016) Rethinking Demethylating Agents in Epigenetic Cancer Therapy. J Mol Pharm Org Process Res 4:133. doi: 10.4172/2329-9053.1000133

Copyright: © Lay FD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

DNA methylation inhibitors 5-Azacytidine and 5-Aza-2’-deoxycytidine have been increasingly used in the clinic to treat myeloid disorders and cancer since their FDA approval over a decade ago. Increasing the efficiency and efficacy of these drugs require better understanding on their mechanism of action. Recent studies show that DNA methylation inhibitors have widespread anti-tumor functions and act by modulating oncogenes and tumor suppressor genes expression as well as stimulating the immune system. These findings demonstrate the significant progress that has been made in the field of epigenetic therapy to improve patients’ outcome.

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