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Retrograde Oxygen Persufflation of Kidney: Experiment on an Animal | OMICS International | Abstract
ISSN: 2161-0991

Journal of Transplantation Technologies & Research
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Research Article

Retrograde Oxygen Persufflation of Kidney: Experiment on an Animal

Molácek J1,2*, Treška V1,2, Opatrný V1, Matejka R3 and Baxa J2

1Department of Surgery, University Hospital in Pilsen, Czech Republic

2Faculty of Medicine in Pilsen, Charles University in Prague, Czech Republic

3Czech Technical University in Prague, Faculty of Biomedical Engineering in Kladno, Czech Republic

*Corresponding Author:
Jiri Molacek
M.D., Ph.D. Department of Surgery
University Hospital in Pilsen Czech Republic
Tel: 420 37710 4275
E-mail: [email protected]

Received Date: June 22, 2015; Accepted Date: July 10, 2015; Published Date: July 19, 2015

Citation: Molácek J, Treška V, Opatrný V, Matejka R, Baxa J (2015) Retrograde Oxygen Persufflation of Kidney: Experiment on an Animal. J Transplant Technol Res 5: 147. doi: 10.4172/2161-0991.1000147

Copyright: © 2015 Molácek J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: There is still a lack of organs for transplantation purposes. In the field of kidney and liver transplantation one of available solutions is the use of organs from so-called marginal donors. These donors can be e.g. non-heartbeating donors (NHBD). In these cases perfusion and preservation of organs intended for transplantation is generally more difficult. Retrograde oxygen persufflation (ROP) may be one of the possible solutions of this issue. This method is based on retrograde perfusion by oxygen through the renal vein thus reconditioning the organ.
Materials and methods: We have operated on 10 animals (porcine models). In all animals was simulated ischemic injury of right kidney. In Group A (N=5) were kidneys after explantation perfused with retrograde oxygen persufflation. In group B (N=5) were kidneys perfused intrarterialy like usually in clinical practice. After perfusion were all kidneys again transplanted to the same animal. Quality of graft restitution was evaluated by urea level taken from renal vein and by histopathological analysis after explantation.
Results: We have found no statistically significant differences between the groups A and B in urea levels after transplantation as wel as we have found no significant differences in quality of kidney parenchyma restoration in both groups.
Conclusions: Retrograde oxygen persufflation is able to protect and restore kidney parenchyma.

Keywords

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