alexa Retropupillary Iris-Claw Intraocular Lens in Ectopia Lentis Due to Marfan Syndrome | OMICS International | Abstract
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
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Case Report

Retropupillary Iris-Claw Intraocular Lens in Ectopia Lentis Due to Marfan Syndrome

Matteo Forlini1, Ana Laura Gramajo2, Robert Rejdak3, Agata Prokopiuk3, Oxana Levkina4, Adriana IonelaBratu5, Paolo Rossini5, Perfecto R Cagampang6, Gian Maria Cavallini1 and Cesare Forlini5*

1Institute of Ophthalmology, University of Modena, Modena, Italy

2Centro Privado de Ojos Romagosa – Fundación VER, Córdoba, Argentina

3Department of Ophthalmology, Medical University of Lublin, Lublin, Poland

4European Medical Center, Moscow, Russia

5Department of Ophthalmology, “Santa Maria Delle Croci” Hospital, Ravenna, Italy

6Eye Referral Center, TM Kalaw, Ermita, Manila, Philippines

*Corresponding Author:
Cesare Forlini
Chief of Department of Ophthalmology
“Santa Maria Delle Croci” Hospital
Viale V. Randi n. 5 , (48121) Ravenna, Italy
Tel: +39 0544 270385
Fax: +39 0544 280049
E-mail: [email protected]

Received date: July 25, 2013; Accepted date:August 12, 2013; Published date: August 14, 2013

Citation: Forlini M, Gramajo AL, Rejdak R, Prokopiuk A, Levkina O, et al. (2013) Retropupillary Iris-Claw Intraocular Lens in Ectopia Lentis Due to Marfan Syndrome. J Genet Syndr Gene Ther 4:170. doi:10.4172/2157-7412.1000170

Copyright: © 2013 Forlini M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Surgical treatment of ectopia lentis in Marfan syndrome cases represents a great challenge for ophthalmic surgeons due to zonular weakness, capsular instability and postoperative aphakia correction. We report three cases of surgical treatment of ectopia lentis due to Marfan syndrome and our approach to aphakia correction by implantation of the retroiridally fixated iris-claw intraocular lens.

Methods: Prospective interventional case series. All patients underwent extraction of the subluxated lens with or without combined vitrectomy. Aphakia correction was performed using the Iris-claw intraocular lens, positioned retroiridally by traditional enclavation of both haptics into iris midperiphery. Patients were followed-up for 6 months. Intraocular lens power was calculated using the SRK-T formula. Diagnosis of Marfan syndrome was confirmed in all cases by molecular diagnosis. Genomic DNA from peripheral blood samples of the patients and their relatives was isolated and screened for fibrillin-1 gene mutations by PCR.

Results: In all cases Iris-claw intraocular lens implantation was carried out uneventfully. In the postoperative period intraocular lens was stable and correctly centered. There were no signs of excessive or prolonged inflammation or any other complications. Intraocular pressure was normal.

Conclusion: Our results suggest that the retroiridally fixated Iris-claw intraocular lens is a very attractive alternative in cases lacking capsular support. It is safe and offers maximal aesthetical and functional results since visual acuity was significantly improved in all patients. However, further evaluation with longer follow-up of a bigger population is desirable.


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