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ISSN: 2472-128X

Journal of Clinical & Medical Genomics
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Review Article

Reverse Direction Method: A Possible Tool to Link Animal Models with Corresponding Human Diseases and Disorders

Rajeev Singh, Toru Atsumi, Hidenori Bando, Masaya Harada, Akihiro Nakamura, Moe Yamada, Jing-Jing Jiang, Hironao Suzuki, Koukiti Katsunuma, Takao Nodomi, Daisuke Kamimura, Hideki Ogura and Masaaki Murakami*

Laboratory of Developmental Immunology, JST-CREST, Graduate School of Frontier Biosciences, Graduate School of Medicine, and WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

*Corresponding Author:
Masaaki Murakami
Innovation Center Building A, Room 401, 2-1
Yamada-oka, Suita, Osaka, Japan 565-0871
Tel: +81-6-6879-4856
Fax: +81-6-6879-4706
E-mail: [email protected]

Received date: July 08, 2013; Accepted date: August 20, 2013; Published date: August 27, 2013

Citation: Singh R, Atsumi T, Bando H, Harada M, Nakamura A, et al. (2013) Reverse Direction Method: A Possible Tool to Link Animal Models with Corresponding Human Diseases and Disorders. Int J Genomic Med 1:106. doi:10.4172/2332-0672.1000106

Copyright: © 2013 Singh R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Animal models are integral to our understanding of the cellular and molecular pathogenesis of human diseases and disorders. Functional genome-wide methods such as DNA microarray and RNA interference-based highthroughput screening have recently emerged as powerful tools for such studies. However, genomic results from animal models may not necessarily correspond to the pathogenesis in humans. Thus, there is a need for new methods that better correlate the data from these models with human disease and disorders. Here we describe the reverse direction method, which combines the in vitro data of genome-wide screening of animal models with the data from genome-wide association studies (GWAS) of human diseases and disorders to effectively link the results of the two. This review introduces the concept of the reverse direction method when applied to the study of the inflammation amplifier, a chemokine inducer in non-immune cells for the development of chronic inflammatory diseases.

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