alexa Review: Adrenal Insufficiency in Liver Disease
ISSN: 2167-0889

Journal of Liver
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Review Article

Review: Adrenal Insufficiency in Liver Disease

Giuseppe Fede*, Luisa Spadaro and Francesco Purrello
Department of Clinical and Molecular Biomedicine, University of Catania-Garibaldi Hospital, Catania, Italy
Corresponding Author : Fede G
Department of Clinical and Molecular Biomedicine
University of Catania-Garibaldi Hospital, Via Palermo 636
95122 Catania, Italy
Tel: (+39) 095 7598702
Fax: 0039-095 7598401
E-mail: [email protected]
Received December 11, 2013; Accepted January 15, 2014; Published January 23, 2014
Citation: Fede G, Spadaro L, Purrello F (2014) Review: Adrenal Insufficiency in Liver Disease. J Liver 3: 146. doi: 10.4172/2167-0889.1000146
Copyright: © 2014 Fede G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Adrenal Insufficiency (AI), defined as deficient production or action of glucocorticoids resulting from either a structural damage of adrenal glands (primary adrenal insufficiency) or an impairment of the hypothalamic-pituitary axis (secondary adrenal disease), is being reported with increasing frequency in patients with liver disease, and some authors proposed the term “hepato-adrenal syndrome”. The prevalence of AI in patients with liver disease varies widely according to the study population: critically ill patients (33-92%), stable cirrhosis (31-60%), or decompensated cirrhosis, such as variceal bleeding (30-48%) and ascites (26-64%). However there is no current consensus about diagnostic criteria to define AI in patients with liver disease, and its prognostic relevance in stable cirrhosis is still unclear.

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