Review Exploring Biological Potentials of Piperazines
Shweta Verma* and Sushil Kumar
Faculty of Pharmacy, IFTM University, Moradabad-244001, India
- *Corresponding Author:
- Shweta Verma
Faculty of Pharmacy, IFTM University
E-mail: [email protected]
Received Date: December 19, 2016; Accepted Date: January 20, 2017; Published Date: January 24, 2017
Citation: Verma S, Kumar S (2017) Review Exploring Biological Potentials of Piperazines. Med Chem (Los Angeles) 7:012-019. doi: 10.4212/2161-0444.1000425
Copyright: © 2017 Verma S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In modernization nitrogen containing heterocyclic compounds and their derivatives has attracted great interest due to their efficacious biological and pharmacological properties. The moiety of piperazines and substituted aryl piperazines were found to present in compounds aim at evaluating new entities that possess anti-microbial, anti-tubercular, anticonvulsant, anti-depressant, anti-malarial and anti-inflammatory activities. Piperazines show a broad range of activities and are found in many potent biologically active compounds such as thiothixene and pimozide (anti-psychotics), Loxapine (schizophrenia), Clozapine (Atypical anti-psychotics). The modifications in the moiety of piperazine ring shows high efficacy with better potency and lesser toxicity. This review focused on multifarious biological activities related to piperazines and its derivatives.