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ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
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Review Article

Review on Nitric Oxide, Carbon Monoxide and Antisense Based Therapy towards Treatment of Restenosis

Prathibha Ramadugu1*, Kanaka Latha Alikatte2, Narendar Dhudipala3 and Vikas Bommasane4

1Talla Padmavathi College of Pharmaceutical Sciences, Warangal, India

2St. Peter’s Institute of Pharmaceutical Sciences, Warangal, India

3University College of Pharmaceutical Sciences, Warangal, India

4Analytical Department, Apotex, India

*Corresponding Author:
Prathibha Ramadugu
Kakatiya Institute of Pharmaceutical Sciences
Pembarthi, Warangal, India
Tel: 040-27626194
Fax: 040-27666347
E-mail: [email protected]

Received Date: December 28, 2015; Accepted Date: January 03, 2016; Published Date: January 10, 2016

Citation: Ramadugu P, Alikatte KL, Dhudipala N, Bommasane V (2016) Review on Nitric Oxide, Carbon Monoxide and Antisense Based Therapy towards Treatment of Restenosis. J Bioequiv Availab 8:059-063. doi:10.4172/jbb.1000268

Copyright: © 2016 Ramadugu P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Balloon angioplasty has shown tremendous improvement in the treatment of atherosclerosis, but arterial renarrowing (restenosis) exists despite the benefits of intravascular devices called stents. Nitric Oxide (NO), carbon monoxide (CO) and Antisense therapy is some of the new potential treatment modalities. NO deficiency is associated with several vascular occlusive diseases, since NO regulates diverse aspects of blood vessel functions. More restricted human studies and several preclinical studies suggest that, NO supplement may solve the restenosis problem, although the data do not conclusively demonstrate this effect. CO, similar to NO, inhibits vascular smooth muscle cells (VSCM) proliferation and in turn relaxes blood vessels and inhibits platelet aggregation. Thus it is recently suggested that inhaling CO could address the restenosis problem. Recent advances in vascular gene transfer have shown positive results for cardiovascular diseases, particularly in the treatment of restenosis. Uncoiling the DNA, transcription of DNA, export of RNA, DNA splicing, RNA stability or RNA transcription involved in the synthesis of proteins in cellular proliferation are some of the process involving antisense based approach. This review focuses on discussing the recent advancements in the treatment of restenosis.

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