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ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
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Review Article

Review-Stem Cells in Neurological Diseases:Indian Perspective

Ashu Bhasin1*, Padma Srivastava MV1*, Rohit Bhatia1, Senthil Kumaran2 and Sujata Mohanty3

1 Department of Neurology, All India Institute of Medical Sciences, India, New Delhi, India

2 Department of NMR, All India Institute of Medical Sciences, India, New Delhi, India

3 Stem Cell Facility, All India Institute of Medical Sciences, India, New Delhi, India

Corresponding Authors:
Ashu Bhasin
Department of Neurology
All India Institute of Medical Sciences
New Delhi, India
Tel: 911126584794
E-mail: [email protected]
Padma Srivastava MV
Department of Neurology
All India Institute of Medical
Sciences, New Delhi, India
E-mail: [email protected]

Received Date: January 20, 2014; Accepted Date: February 21, 2014; Published Date: February 24, 2014

Citation: Bhasin A, Padma Srivastava MV, Bhatia R, Kumaran S, Mohanty S (2014) Stem Cells in Neurological Diseases: Indian Perspective. J Stem Cell Res Ther 4:175. doi:10.4172/2157-7633.1000175

Copyright: © 2014 Bhasin A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Stem cell therapy is under investigation in neurological diseases with currently sub optimal or no treatment available. They are hypothesized to produce new cells, or act as “chaperones or scaffolds” to repair and reconstruct neuronal circuitry and release the relevant neurotransmitters for ultimate functional improvement in the individual. They have the potential either to divide or multiply or differentiate into one or more cell type, usually in response to some kind of signal. In recent years, bone marrow derived stem cells have been successfully exploited as neurorestorative tool to augment brain recovery. In this review we have discussed the types and sources of stem cells, notable clinical studies published and ongoing trials in India involving Stroke, Parkinson’s disease, Spinal cord injury, ALS, Multiple Sclerosis etc and discuss the future prospects for more trials. All these studies proved the safety and feasibility of cell transplantation. Steady and focused progress in stem cell research in both preclinical and clinical settings in Indian subcontinent should support the hope for development of cell-based therapies as treatment in near future.

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