alexa Rheumatoid Arthritis and Alzheimer Disease: Possible Ce
ISSN: 2167-7182

Journal of Gerontology & Geriatric Research
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Rheumatoid Arthritis and Alzheimer Disease: Possible Cellular and Molecular Links

Gianfranco Ferraccioli*, Elisa Gremese, Angela Carbonella and Stefano Alivernini
Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy
Corresponding Author : Gianfranco Ferraccioli
Professor of Rheumatology
Division of Rheumatology
Institute of Rheumatology and Affine Sciences
Catholic University of the Sacred Heart, Italy
Tel: 0039-06-3503654
E-mail: [email protected]
Received March 16, 2012; Accepted March 19, 2012; Published March 24, 2012
Citation: Ferraccioli G, Gremese E, Carbonella A, Alivernini S (2012) Rheumatoid Arthritis and Alzheimer Disease: Possible Cellular and Molecular Links. J Gerontol Geriat Res 1:e104. doi:10.4172/2167-7182.1000e104
Copyright: © 2012 Ferraccioli G et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Alzheimer disease (AD) is the most common form of dementia of the old population over 85 years. AD pathogenesis is multifactorial and several findings support the neuroinflammatory pathogenetic hypothesis. There is an inverse relationship between AD and Rheumatoid arthritis (RA) due to different factors. Among them, NSAIDs use acting both on amyloid formation and COX enzymes has been supposed to play a protective role on AD risk. Moreover, new insights on colony stimulating factors (GM-CSF, M-CSF and G-CSF) pathways in immune cells differentiation suggested a possible cellular link between AR and the AD onset.

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