Risk Factors in the Development of Stroke in an Outpatient Cardiology Practice
|Hoang M. Lai1, Wilbert S. Aronow1*, Anthony D. Mercando2, Phoenix Kalen1, Harit V. Desai1, Kaushang Gandhi1, Mala Sharma1, Harshad Amin1 and Trung M. Lai1|
|1From the Department of Medicine, New York Medical College, Valhalla, New York, USA|
|2Westchester Cardiology Associates/WestMed Medical Group and Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA|
|Corresponding Author :||Wilbert S. Aronow
MD, FACC, FAHA, Cardiology Division
New York Medical College, Macy Pavilion
Room 138, Valhalla, New York, USA
Tel: (914) 493-5311
Fax: (914) 235-6274
E-mail: [email protected]
|Received September 15, 2011; Accepted October 06, 2011; Published October 12, 2011|
|Citation: Lai HM, Aronow WS, Mercando AD, Kalen P, Desai HV, et al. (2011) A Case of 2:1 Atrio -Ventricular Block in Digoxin Toxicity. J Clinic Experiment Cardiol 2:156. doi:10.4172/2155-9880.1000156|
|Copyright: © 2011 Lai HM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Purpose: The aim of this study was to determine the risk factors in the development of stroke in an outpatient cardiology practice.
Methods: Chart reviews were performed in 1,599 patients (1138 men and 461 women), mean age 72 ± 12 years. Medication use and comorbidities were tabulated for each patient. Stepwise Cox regression analyses were used to analyze 45 different variables for statistical significance. The mean follow-up duration was 63 ± 55 months during 1977 to 2009.
Results: Of the 1, 599 patients, stroke occurred in 48 patients (3%) during follow-up. Stepwise Cox regression analysis showed significant independent risk factors for new stroke were statins (hazard ratio = 0.2656, 95% CI, 0.1480 to 0.4766, p <0.0001), carotid artery stenosis (hazard ratio = 3.7292, 95% CI, 1.7960 to 7.7433, p<0.001), and congestive heart failure (hazard ratio = 2.1369, 95% CI, 1.1046 to 4.1340, p <0.05).
Conclusions: In an outpatient cardiology practice, use of statins reduced the incidence of stroke by 73%. Carotid artery stenosis and congestive heart failure increased the risk of developing stroke by 3.7 times and 2.1 times, respectively.