Risk of Chronic Kidney Disease after Early and Late Helicobacter Pylori Eradication in Patients with Peptic Ulcer Disease: A Population-Based Cohort Study in TaiwanGuei-Fen Chiu1*, Yu-Han Chang1, Den-Chang Wu1,2,4, Ming-Tsang Wu4 and Hugo You-Hsien Lin1,3
- *Corresponding Author:
- Guei Fen Chiu
Department of Internal Medicine
Kaohsiung Municipal Ta-Tung Hospital
Kaohsiung Medical University, Taiwan
E-mail: [email protected]
Received Date: May 22, 2017; Accepted Date: June 26, 2017; Published Date: July 03, 2017
Citation: Chiu GF, Chang YH, Wu DC, Wu MT, Lin HYH (2017) Risk of Chronic Kidney Disease after Early and Late Helicobacter pylori Eradication in Patients with Peptic Ulcer Disease: A Population-Based Cohort Study in Taiwan. Biol Med (Aligarh) 9: 402. doi: 10.4172/0974-8369.1000402
Copyright: © 2017 Chiu GF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Helicobacter pylori play a central role in the development of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. The risk of upper gastrointestinal bleeding in patients with chronic kidney disease (CKD) or end stage renal disease is reportedly higher than that in the general population. The effects of early and late H. pylori eradication on kidney disease rates warrant further investigation. Methods: We conducted a population-based study by using Taiwan’s National Health Insurance Research Database of 1 million beneficiaries. The enrolled-date of this database is from January 1, 2000 to December 31, 2009. We compared the incidence and risk of CKD in 3,689 patients in the early H. pylori eradication cohort with those in 4,298 patients in the late H. pylori eradication cohort. Results: The adjusted hazard ratio (HR; 95% confidence interval (CI)=1.17–1.77) for subsequent CKD was 1.44-fold higher in the late eradication cohort than in the early eradication cohort. In subgroup analysis, in patients aged 40–65 years, the HR was 1.55 (95% CI=1.14–2.10) and in those aged >65 years, the HR was 1.41 (95% CI=1.03–1.93). Conclusion: This nationwide population-based cohort study provides evidence that patients with late eradication of H. pylori are at higher risk of CKD than those with early eradication of H. pylori.