alexa Rituximab for Treatment of Focal Segmental Glomerulosclerosis in a Child: A Case Report | OMICS International | Abstract
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
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Case Report

Rituximab for Treatment of Focal Segmental Glomerulosclerosis in a Child: A Case Report

Zhengkun Xia*, Yu Zhou*, Yuanfu Gao*, Zhongmin Fan*, Chunlin Gao, Song Mao, Xu He, Zhuo Shi, Tao Sun, Pei Zhang, Hongjun Peng and
Min Xu

Department of Pediatrics, Nanjing Jinling Hospital, China

*Corresponding Author:
Zhengkun Xia
Department of Pediatrics, Nanjing Jinling Hospital
305 East Road, ZhongShan, Nanjing 210002, P. R. China
Tel: +86 25 80861386
E-mail: [email protected]

Yu Zhou
Department of Pediatrics, Nanjing Jinling Hospital
305 East Road ZhongShan, Nanjing 210002, P.R.China
Tel: (+86 25) 80861386
E-mail: [email protected]

Yuanfu Gao
Department of Pediatrics, Nanjing Jinling Hospital
305 East Road ZhongShan, Nanjing 210002, P.R.China
Tel: (+86 25) 80861386
E-mail: [email protected]

Zhongmin Fan
Department of Pediatrics, Nanjing Jinling Hospital
305 East Road ZhongShan, Nanjing 210002, P.R.China
Tel: (+86 25) 80861386
E-mail: [email protected]

Received Date: February 17, 2014; Accepted Date: March 24, 2014; Published Date: March 27, 2014

Citation: Xia Z, Zhou Y, Gao Y, Fan Z, Gao C, et al. (2014) Rituximab for Treatment of Focal Segmental Glomerulosclerosis in a Child: A Case Report. J Nephrol Therapeutic S1:009. doi:10.4172/2161-0959.S1-009

Copyright: © 2014 Xia Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To study the efficacy of rituximab in children with focal sclerosing glomerulonephritis (FSGS). Case Report: Before treatment, blood biochemistry, hepatic and renal function, differential white cell counts, immunoglobulins and the complement system were assessed. Promethazine (0.5-1 mg/kg) and methylprednisolone (0.1-0.3 mg/kg) were administered intravenously 30 min and 5-10 min before the rituximab infusion. Rituximab (0.27 g) was diluted in 300 ml glucose solution and initially administered at 50 ml/hr the rate increased to 50 ml/hr every 30 min after no side effects occurred in the first hour. A second dose was given one month later. During treatment, prednisone (30mg) was taken on alternate days. Benazepril (3.3 mg) was administered every day with one chongcao capsule. Homemade ershenkang was given three times a day. Outcome: Eyelid and limb edema declined two weeks after the first application of rituximab and resolved after the second treatment. Urinary protein levels decreases, serum albumin increased, and white cell counts, hepatic function and renal function remained constant. After 3 months of followup, urine protein decreased significantly, and serum albumin (35.2 g/L) and cholesterol (5.4 mmol/L) normalized. Parameters of immune activation also reduced, and the patient remained well. Conclusion: In this case, rituximab was a safe and efficacious treatment for FSGS.

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