alexa Rivastigimine for Relatively Younger Alzheimer's Disease Patient
ISSN: 2168-975X

Brain Disorders & Therapy
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Case Report

Rivastigimine for Relatively Younger Alzheimer's Disease Patient

Kentaro Horiuchi1, Koji Hori1*, Misa Hosoi1, Kimiko Konishi1,2, Hiroi Tomioka1 and Mitsugu Hachisu3
1Department of Psychiatry, Showa University Northern Yokohama Hospital, Kanagawa, Japan
2Tokyo Metropolitan Tobu Medical Center for Persons With Developmental/Multiple Disabilities, Tokyo, Japan
3Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
Corresponding Author : Koji Hori
Department of Psychiatry
Showa University Northern Yokohama Hospital
35-1 Chigasakichuo, Tsuzukiku
Yokohama-City, Kanagawa, 224-8503, Japan
Tel: +81-45-949-7000
Fax: +81-45-949-7927
E-mail: [email protected]
Received date: May 09, 2014, Accepted date: June 16, 2014, Published date: June 27, 2014
Citation: Horiuchi H, Hori K, Hosoi M, Konishi K, Tomioka H (2014) Rivastigimine for Relatively Young er Alzheimer’s Disease Patient. Brain Disord Ther 3:133. doi:10.4172/2168-975X.1000133
Copyright: © 2014 Hiruichi K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We presented the patient with relative younger Alzheimer’s disease (AD) whose clinical symptoms and cognitive functions were responsive not to donepezil but to rivastigmine. Age of initial visit our memory clinic of this patient was relatively younger. It is considered that in relative older patient both AD pathology and aging cause cognitive dysfunctions. However, in relative younger patient not aging but only AD pathology causes cognitive dysfunctions. Therefore, AD pathology was thought to be more pronounced in our patient than relatively older patients with same cognitive disturbances. In AD, glia cells and amyloids proliferate and nervous cells shrink. Butyrylcholinesterase (BuChE) exists in glia cells and amyloids. Therefore, when AD progresses, acetylcholinesterase (AChE) decreases and BuChE increases. Accordingly the ratio of BuChE/AChE increases. Therefore, when at mild stage such our patient, not donepezil but rivastigmine which has inhibiting actions on both AChE and BuChE was suitable.

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