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ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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Review Article

RNA Interference (RNAi) - An antiviral Strategy for Enteroviruses

Eng Lee Tan1,2* and Justin Jang Hann Chu3

1Centre for Biomedical and Life Sciences, Singapore Polytechnic, Singapore

2Department of Paediatrics, University Children’s Medical Institute, National University Health System, National University Hospital, Singapore

3Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore

*Corresponding Author:
Eng Lee Tan
Centre for Biomedical and Life Sciences
Department of Paediatrics
University Children’s Medical Institute
National University Health System
National University Hospital Singapore Polytechnic
Tel: 65-68790604
E-mail: [email protected]

Received Date: June 24, 2011; Accepted Date: July 22, 2011; Published Date: July 25, 2011

Citation: Tan EL, Hann Chu JJ (2011) RNA Interference (RNAi) - An antiviral Strategy for Enteroviruses. J Antivir Antiretrovir S9:002. doi: 10.4172/jaa.S9-002

Copyright: © 2011 Tan EL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Human enteroviruses are a genus of RNA viruses which affects millions of people worldwide each year. They are associated with wide spectrum of diseases ranging from mild respiratory illness like the common cold, hand, foot and mouth disease (HFMD) to more severe neurological and cardiac complications which are fatal. Currently, there is no an effective vaccine or specific antiviral treatment to prevent or treat non-polio enteroviral infections. Since its discovery in 1998, RNA interference has emerged as a potential therapeutic strategy against infectious diseases. In this review, we focus on the developments of using RNAi to prevent or treat enteroviral infections, highlighting the potential of RNAi as a potential antiviral strategy against enteroviruses.

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