alexa RNA Interference (RNAi) as a Metronome of the Circadian Cadence
ISSN: 2168-9547

Molecular Biology: Open Access
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Review Article

RNA Interference (RNAi) as a Metronome of the Circadian Cadence

Utpal Bhadra1*, Paromita Das2 and Manika Pal-Bhadra2

1Functional Genomics and Gene Silencing Group, Centre for Cellular and Molecular Biology, Hyderabad-500007, India

2Centre for Chemical Biology, Indian Institute of Chemical Technology, Hyderabad-500007, India

*Corresponding Author:
Utpal Bhadra
Functional Genomics and Gene Silencing Group
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India-50007
Tel: 91-40-27192513
Fax: 91-40-27160591
E-mail: [email protected]

Received date: June 17, 2016; Accepted date: June 21, 2016; Published date: June 28, 2016

Citation: Bhadra U, Das P, Pal-Bhadra M (2016) RNA Interference (RNAi) as a metronome of the circadian cadence. Mol Biol 5:166. doi:10.4172/2168-9547.1000166

Copyright: © 2016 Bhadra U, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




The circadian clock of an organism is intricately entwined between a multitude of intercellular and intracellular networks consolidating the physiological activities into a refined rhythmic pattern. The key to these rhythms lie in their exceptional competence in either self-sustaining or in resetting themselves to the most suitable stimuli, neglecting the irrelevant ones. Apart from the prevalent notion about the dominant role of transcription and translation in the clock regulation, recent findings have unfurled the importance of post-transcription and post-translation in modulating the same. This review aims at evolving a new player in clock control via the incredible phenomena of RNA interference (RNAi), which is executed mainly through the microRNAs and the long non-coding RNAs. It enlightens us with replete evidences that effectively establish the cryptic yet enigmatic role of different core components of RNA interference and their machinery in the modulation of all the unexplored facets for the sustenance and constancy of the biological rhythm.


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